• An epigenetic clock for human skeletal muscle 

      Voisin, Sarah; Harvey, Nicholas R; Haupt, Larisa M; Griffiths, Lyn R; Aston, Kevin J; Coffey, Vernon G.; Doering, Thomas M; Thompson, Jamie-Lee M; Benedict, Christian; Cedernaes, Jonathan; Lindholm, Malene E; Craig, Jeffrey M; Rowlands, David S; Sharples, Adam; Horvath, Steve; Eynon, Nir (Peer reviewed; Journal article, 2020)
      Background: Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the ...
    • Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle 

      Voisin, Sarah; Jacques, Macsue; Landen, Shanie; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Gancheva, Sofiya; Ouni, Meriem; Jähnert, Marcus; Ashton, Kevin J.; Coffey, Vernon G.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Gabory, Anne; Junien, Claudine; Caiazzo, Robert; Verkindt, Hélène; Raverdy, Violetta; Pattou, Francois; Froguel, Philippe; Blocquiaux, Sara; Thomis, Martine; Roden, Michael; Horvath, Steve; Eynon, Nir; Craig, Jeffrey M.; Sharples, Adam P.; Schürmann, Annette (Peer reviewed; Journal article, 2021)
      Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ...