Fat-free mass mediates the association between birth weight and aerobic fitness in youth
Ridgway, C. L.; Brage, Søren; Anderssen, Sigmund A.; Sardinha, Luis B.; Andersen, Lars Bo; Ekelund, Ulf
Journal article, Peer reviewed
Permanent lenke
http://hdl.handle.net/11250/170897Utgivelsesdato
2011-06Metadata
Vis full innførselSamlinger
- Artikler / Articles [2096]
Originalversjon
International Journal of Pediatric Obesity. 2011, 6(2-2), e590-e596Sammendrag
Objective: To investigate whether birth weight acts as a biological determinant of later
aerobic fitness, and whether fat free mass may mediate this association.
Methods: The European Youth Heart Study (EYHS) is a population based cohort of
two age groups (10 and 15 years) from Denmark, Portugal, Estonia and Norway.
Children with parentally reported birth weight >1.5kg were included (n=2,749). Data
was collected on weight, height, and skin fold measures to estimate fat mass and fat free
mass. Aerobic fitness (peak power, watts) was assessed using a maximal, progressive
cycle ergometer test. Physical activity was collected in a subset (n=1,505) using a hipworn
accelerometer and defined as total activity counts/wear time, all children with
>600 minutes/day for 3 days of wear were included.
Results: Lower birth weight was associated with lower aerobic fitness, after adjusting
for sex, age group, country, sexual maturity and socio-economic status (ß=5.4, 95%CI
3.5, 7.3 W per 1kg increase in birth weight, p<0.001). When fat free mass was
introduced as a covariate in the model, the association between birth weight and aerobic
fitness was almost completely attenuated (p=0.7). Birth weight was also significantly
associated with fat free mass (ß=1.4 95%CI 1.1, 1.8, p<0.001) and fat free mass was
significantly associated with aerobic fitness (ß=3.6, 95%CI 3.4, 3.7, p<0.001). Further
adjustment for physical activity did not alter the findings.
Conclusion: Birth weight may have long-term influences on fat free mass and
differences in fat free mass mediate the observed association between birth weight and
aerobic fitness.
Beskrivelse
I Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på www.informahealthcare.com: http://dx.doi.org/10.3109/17477166.2010.526225 / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The original publication is available at www.informahealthcare.com: http://dx.doi.org/10.3109/17477166.2010.526225