Exhaled nitric oxide and lung function after moderate normobaric hyperoxic exposure
Journal article, Peer reviewed
Permanent lenke
http://hdl.handle.net/11250/192660Utgivelsesdato
2013Metadata
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Originalversjon
Undersea & Hyperbaric Medicine. 2013, 40, 7-13Sammendrag
Pulmonary oxygen toxicity is associated
with inflammatory responses in the airways and
alveoli. The purpose of this study was to investigate
whether the changes in exhaled nitric oxide (FENO)
after exposure to normobaric hyperoxia (NBO),
100% oxygen (O2) at 1 atmosphere absolute (atm
abs) for 90 minutes, are associated with changes
in lung function.
Methods: Eighteen healthy non-smoking subjects
were exposed to NBO breathing 100% oxygen and
to breathing ambient air, both for 90 minutes on
separate days and in random order. Dynamic and
static lung volumes, maximal expiratory flow rates,
distribution of ventilation including closing volume
and slope of phase III of the nitrogen washout
curve (Δ N2), diffusion capacity (DLCO) and FENO
were measured before and after the exposures.
Results: The mean reduction in FENO was 20%
(SD=20) after the NBO exposure (p<0.001). Static and
dynamic lung volumes, maximal expiratory flow rates,
DLCO and distribution of ventilation were unchanged.
No association was found between the changes in
the lung function variables and the change in FENO.
Discussion: Unchanged indices of distribution of
ventilation and maximal expiratory flow rates indicate
no small airways’ dysfunction, and unchanged DLCO
suggests preserved gas transfer in the lung despite a
significant reduction in FENO. FENO might be an index
of oxygen exposure, but further studies over a wide
range of oxygen exposures are necessary to establish the
role of FENO as a marker of pulmonary oxygen toxicity.
Beskrivelse
© 2013 Undersea & Hyperbaric Medical Society, Inc.