dc.contributor.author | Årøen, Asbjørn | |
dc.contributor.author | Brøgger, Helga Marie | |
dc.contributor.author | Røtterud, Jan Harald | |
dc.contributor.author | Sivertsen, Einar Andreas | |
dc.contributor.author | Engebretsen, Lars | |
dc.contributor.author | Risberg, May Arna | |
dc.date.accessioned | 2016-05-25T12:25:45Z | |
dc.date.available | 2016-05-25T12:25:45Z | |
dc.date.issued | 2016 | |
dc.identifier.citation | BMC Musculoskeletal Disorders. 2016, 17, 73 | nb_NO |
dc.identifier.uri | http://hdl.handle.net/11250/2390418 | |
dc.description | © 2016 Årøen et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. | nb_NO |
dc.description.abstract | Background: Assessment of degenerative changes of the cartilage is important in knee cartilage repair surgery.
Magnetic Resonance Imaging (MRI) T2 mapping and delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) are
able to detect early degenerative changes. The hypothesis of the study was that cartilage surrounding a focal cartilage
lesion in the knee does not possess degenerative changes.
Methods: Twenty-eight consecutive patients included in a randomized controlled trial on cartilage repair were
evaluated using MRI T2 mapping and dGEMRIC before cartilage treatment was initiated. Inclusion was based on
disabling knee problems (Lysholm score of ≤ 75) due to an arthroscopically verified focal femoral condyle cartilage
lesion. Furthermore, no major malalignments or knee ligament injuries were accepted. Mean patient age was 33 ±
9.6 years, and the mean duration of knee symptoms was 49 ± 60 months. The MRI T2 mapping and the dGEMRIC
measurements were performed at three standardized regions of interest (ROIs) at the medial and lateral femoral
condyle, avoiding the cartilage lesion
Results: The MRI T2 mapping of the cartilage did not demonstrate significant differences between condyles with
or without cartilage lesions. The dGEMRIC results did not show significantly lower values of the affected condyle
compared with the opposite condyle and the contra-lateral knee in any of the ROIs. The intraclass correlation
coefficient (ICC) of the dGEMRIC readings was 0.882.
Conclusion: The MRI T2 mapping and the dGEMRIC confirmed the arthroscopic findings that normal articular
cartilage surrounded the cartilage lesion, reflecting normal variation in articular cartilage quality. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | BioMed Central | nb_NO |
dc.subject | knee | nb_NO |
dc.subject | cartilage lesion | nb_NO |
dc.subject | dGEMRIC, | nb_NO |
dc.subject | MRI | nb_NO |
dc.subject | T2-mapping | nb_NO |
dc.title | Evaluation of focal cartilage lesions of the knee using MRI T2 mapping and delayed Gadolinium Enhanced MRI of Cartilage (dGEMRIC) | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.subject.nsi | VDP::Medical disciplines: 700 | nb_NO |
dc.subject.nsi | VDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710 | nb_NO |
dc.subject.nsi | VDP::Medical disciplines: 700::Health sciences: 800 | nb_NO |
dc.source.journal | BMC Musculoskeletal Disorders | nb_NO |
dc.description.localcode | Seksjon for idrettsmedisinske fag / Department of Sports Medicine | nb_NO |