A mango leaf extract (Zynamite®) combined with Quercetin has exercise-mimetic properties in human skeletal muscle
dc.contributor.author | Martinez-Canton, Miriam | |
dc.contributor.author | Galvan-Alvarez, Victor | |
dc.contributor.author | Garcia-Gonzalez, Eduardo | |
dc.contributor.author | Gallego-Selles, Angel | |
dc.contributor.author | Gelabert-Rebato, Miriam | |
dc.contributor.author | Garcia-Perez, Giovanni | |
dc.contributor.author | Santana, Alfredo | |
dc.contributor.author | Lopez-Rios, Laura | |
dc.contributor.author | Vega-Morales, Tanausu | |
dc.contributor.author | Martin-Rincon, Marcos | |
dc.contributor.author | Calbet, Jose Antonio Lopez | |
dc.date.accessioned | 2024-03-15T09:33:17Z | |
dc.date.available | 2024-03-15T09:33:17Z | |
dc.date.created | 2023-09-13T10:24:25Z | |
dc.date.issued | 2023 | |
dc.identifier.citation | Nutrients. 2023, 15(13), Artikkel 2848. | en_US |
dc.identifier.issn | 2072-6643 | |
dc.identifier.uri | https://hdl.handle.net/11250/3122568 | |
dc.description | This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | en_US |
dc.description.abstract | Zynamite PX®, a mango leaf extract combined with quercetin, enhances exercise performance by unknown molecular mechanisms. Twenty-five volunteers were assigned to a control (17 males) or supplementation group (8 males, receiving 140 mg of Zynamite® + 140 mg quercetin/8 h for 2 days). Then, they performed incremental exercise to exhaustion (IE) followed by occlusion of the circulation in one leg for 60 s. Afterwards, the cuff was released, and a 30 s sprint was performed, followed by 90 s circulatory occlusion (same leg). Vastus lateralis muscle biopsies were obtained at baseline, 20 s after IE (occluded leg) and 10 s after Wingate (occluded leg), and bilaterally at 90 s and 30 min post exercise. Compared to the controls, the Zynamite PX® group showed increased basal protein expression of Thr287-CaMKIIδD (2-fold, p = 0.007) and Ser9-GSK3β (1.3-fold, p = 0.005) and a non-significant increase of total NRF2 (1.7-fold, p = 0.099) and Ser40-NRF2 (1.2-fold, p = 0.061). In the controls, there was upregulation with exercise and recovery of total NRF2, catalase, glutathione reductase, and Thr287-CaMKIIδD (1.2–2.9-fold, all p < 0.05), which was not observed in the Zynamite PX® group. In conclusion, Zynamite PX® elicits muscle signaling changes in resting skeletal muscle resembling those described for exercise training and partly abrogates the stress kinases responses to exercise as observed in trained muscles. | en_US |
dc.language.iso | eng | en_US |
dc.subject | antioxidant supplementation | en_US |
dc.subject | ergogenic aids | en_US |
dc.subject | high-intensity exercise | en_US |
dc.subject | human | en_US |
dc.subject | ischaemia-reperfusion | en_US |
dc.subject | muscle function | en_US |
dc.subject | polyphenols | en_US |
dc.subject | signaling | en_US |
dc.subject | sports nutrition | en_US |
dc.title | A mango leaf extract (Zynamite®) combined with Quercetin has exercise-mimetic properties in human skeletal muscle | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2023 by the authors | en_US |
dc.source.pagenumber | 22 | en_US |
dc.source.volume | 15 | en_US |
dc.source.journal | Nutrients | en_US |
dc.source.issue | 13 | en_US |
dc.identifier.doi | 10.3390/nu15132848 | |
dc.identifier.cristin | 2174595 | |
dc.description.localcode | Institutt for fysisk prestasjonsevne / Department of Physical Performance | en_US |
dc.source.articlenumber | 2848 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 |
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