• Aging, Skeletal Muscle, and Epigenetics 

      Stewart, Claire E.; Sharples, Adam (Peer reviewed; Journal article, 2022)
      We are living in an aging society. In 2019, 1 billion individuals were already aged over 60. The number of people in this demographic is predicted to reach 1.4 billion by 2030 and 2.1 billion by 2050 (WHO). In the USA, ...
    • Alpine skiing with total knee arthroplasty (ASWAP): muscular adaptations 

      Rieder, Florian; Kösters, Alexander; Wiesinger, Hans-Peter; Dorn, U.; Hofstaedter, T.; Fink, Christian; Müller, Erich; Seynnes, Olivier R. (Journal article; Peer reviewed, 2015-06-17)
      This study investigated the effectiveness of recreational skiing as an intervention to improve quadriceps muscle architecture, strength, and antagonistic co-activation in patients with unilateral total knee arthroplasty ...
    • Effect of high-intensity training on bone health and body composition in lung transplant recipients: A secondary analysis of a randomized controlled trial 

      Ulvestad, Mariann; Godang, Kristin; Durheim, Michael T.; Kongerud, Johny S.; Bollerslev, Jens; Edvardsen, Elisabeth; Lund, May-Brit (Peer reviewed; Journal article, 2021)
      Background: Loss of bone mineral and skeletal muscle mass is common after lung transplantation (LTx), and physical activity (PA) may prevent further deterioration. We aimed to assess the effects of 20-week high-intensity ...
    • Musculoskeletal adaptations to strength training in frail elderly: A matter of quantity or quality? 

      Aas, Sigve Nyvik; Breit, Markus; Karsrud, Stian; Aase, Ole Jølle; Rognlien, Simen Helset; Cumming, Kristoffer Toldnes; Reggiani, Carlo; Seynnes, Olivier R.; Rossi, Andrea; Toniolo, Luana; Raastad, Truls (Peer reviewed; Journal article, 2020)
      Background The improvement in muscle strength generally exceeds the increase in muscle size following strength training in frail elderly, highlighting the complex aetiology of strength deficit in aging. The aim of this ...
    • Physiological and functional evaluation of healthy young and older men and women: design of the European MyoAge study 

      McPhee, Jamie S.; Hogrel, Jean-Yves; Maier, Andrea B.; Seppet, Enn; Seynnes, Olivier R.; Sipilä, Sarianna; Bottinelli, Roberto; Barnouin, Yoann; Bijlsma, Astrid Y.; Gapeyeva, Helena; Maden-Wilkinson, Thomas M.; Meskers, Carel G.; Pääsuke, Mati; Sillanpää, Elina; Sentroth, Lauri; Butler-Browne, Gillian; Narici, Marco V.; Jones, David A. (Journal article; Peer reviewed, 2013-05-31)
      Within the European multi-centre MyoAge project, one workpackage was designed to investigate the contribution of age-related changes to muscle mass, contractile characteristics and neural control in relation to reductions ...
    • Strength training and protein supplementation improve muscle mass, strength, and function in mobility-limited older adults: a randomized controlled trial 

      Aas, Sigve Nyvik; Seynnes, Olivier R.; Benestad, Haakon Breien; Raastad, Truls (Peer reviewed; Journal article, 2019)
      Background Adaptation to strength training in very old mobility-limited individuals is not fully characterized. Therefore, the aim of this study was to perform a thorough investigation of the adaptation to a lower body ...
    • Ubiquitin ligases in longevity and aging skeletal muscle 

      Hughes, David C.; Baehr, Leslie M.; Waddell, David S.; Sharples, Adam; Bodine, Sue C. (Peer reviewed; Journal article, 2022)
      The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome ...