• Caffeine increases performance in cross-country double-poling time trial exercise 

      Stadheim, Hans Kristian; Kvamme, Bent; Olsen, Raymond; Ivy, John L.; Drevon, Christian A.; Ivy, John L.; Jensen, Jørgen (Journal article; Peer reviewed, 2013-11)
      PURPOSE: Caffeine (CAF) improves performance in both short- and long-duration running and cycling where performance relies on power output and endurance capacity of leg muscles. No studies have so far tested ...
    • Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging 

      Lee, Sindre; Norheim, Frode; Langleite, Torgrim M.; Noreng, Hans J.; Storås, Trygve H.; Afman, Lydia A.; Frost, Gary; Bell, Jimmy D.; Thomas, E. Louise; Kolnes, Kristoffer J.; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor D.; Gulseth, Hanne L.; Birkeland, Kåre I.; Jensen, Jørgen; Drevon, Christian A.; Holen, Torgeir (Journal article; Peer reviewed, 2016-11-07)
      Overweight and obesity lead to changes in adipose tissue such as inflammation and reduced insulin sensitivity. The aim of this study was to assess how altered energy balance by reduced food intake or enhanced physical ...
    • Evidence against a beneficial effect of irisin in humans 

      Raschke, Silja; Elsen, Manuela; Gassenhuber, Hans; Sommerfeld, Mark; Schwahn, Uwe; Brockmann, Barbara; Jung, Raphael; Wisløff, Ulf; Tjønna, Arnt E.; Raastad, Truls; Hallén, Jostein; Norheim, Frode; Drevon, Christian A.; Romacho, Tania; Eckardt, Kristin; Eckel, Juergen (Journal article; Peer reviewed, 2013-09-11)
      Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves ...
    • Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise 

      Gjevestad, Gyrd O.; Hamarsland, Håvard; Raastad, Truls; Ottestad, Inger; Christensen, Jacob J.; Eckardt, Kristin; Drevon, Christian A.; Biong, Anne S.; Ulven, Stine M.; Holven, Kirsten B. (Journal article; Peer reviewed, 2017-03-03)
      Background: High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expression ...
    • Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines 

      Pourteymour, Shirin; Eckardt, Kristin; Holen, Torgeir; Langleite, Torgrim Mikal; Lee, Sindre; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A.; Hjorth, Marit (Journal article; Peer reviewed, 2017-01)
      Objective: Skeletal muscle is an important secretory organ, producing and releasing numerous myokines, which may be involved in mediating beneficial health effects of physical activity. More than 100 myokines have been ...
    • Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise 

      Lee, Sindre; Norheim, Frode; Gulseth, Hanne L.; Langleite, Torgrim M.; Kolnes, Kristoffer J.; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor D.; Holen, Torgeir; Birkeland, Kåre I,; Jensen, Jørgen; Drevon, Christian A. (Journal article; Peer reviewed, 2017-03)
      The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be ...
    • Molecular nutrition research: the modern way of performing nutritional science 

      Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild; Drevon, Christian A. (Journal article; Peer reviewed, 2012-12-03)
      In spite of amazing progress in food supply and nutritional science, and a striking increase in life expectancy of approximately 2.5 months per year in many countries during the previous 150 years, modern nutritional ...
    • Regulation of angiopoietin-like protein 4 Production during and after exercise 

      Norheim, Frode; Hjorth, Marit; Langleite, Torgrim Mikal; Lee, Sindre; Holen, Torgeir; Bindesbøll, Christian; Stadheim, Hans Kristian; Gulseth, Hanne Lovdal; Birkeland, Kåre I.; Kielland, Anders; Jensen, Jørgen; Dalen, Knut Tomas; Drevon, Christian A. (Journal article; Peer reviewed, 2014-08-19)
      Angiopoietin-like protein 4 (ANGPTL4) may regulate lipoprotein lipase-dependent plasma clearance of triacylglycerol from skeletal muscle during exercise. The aim of this study was to examine the importance of muscle in ...
    • Subsarcolemmal lipid droplet responses to a combined endurance and strength exercise intervention 

      Li, Yuchuan; Lee, Sindre; Langleite, Torgrim; Norheim, Frode; Pourteymour, Shirin; Jensen, Jørgen; Stadheim, Hans Kristian; Storås, Tryggve H.; Davanger, Svend; Gulseth, Hanne L.; Birkeland, Kåre I.; Drevon, Christian A.; Holen, Torgeir (Journal article; Peer reviewed, 2014)
      Muscle lipid stores and insulin sensitivity have a recognized association although the mechanism remains unclear. We investigated how a 12‐week supervised combined endurance and strength exercise intervention influenced ...
    • The effect of acute and long‐term physical activity on extracellular matrix and serglycin in human skeletal muscle 

      Hjorth, Marit; Norheim, Frode; Meen, Astri Jeanette; Pourteymour, Shirin; Lee, Sindre; Holen, Torgeir; Jensen, Jørgen; Birkeland, Kåre I.; Martinov, Vladimir Nikolkaev; Langleite, Torgrim Mikal; Eckardt, Kristin; Drevon, Christian A.; Kolset, Svein Olav (Journal article; Peer reviewed, 2015-08-19)
      Remodeling of extracellular matrix (ECM), including regulation of proteoglycans in skeletal muscle can be important for physiological adaptation to exercise. To investigate the effects of acute and long‐term exercise on ...