• Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise 

      Pourteymour, Shirin; Hjorth, Marit; Lee-Ødegård, Sindre; Holen, Torgeir; Langleite, Torgrim Mikal; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A; Eckardt, Kristin (Journal article; Peer reviewed, 2017)
      Physical activity promotes specific adaptations in most tissues including skeletal muscle. Acute exercise activates numerous signaling cascades including pathways involving mitogen‐activated protein kinases (MAPKs) such ...
    • Evidence against a beneficial effect of irisin in humans 

      Raschke, Silja; Elsen, Manuela; Gassenhuber, Hans; Sommerfeld, Mark; Schwahn, Uwe; Brockmann, Barbara; Jung, Raphael; Wisløff, Ulf; Tjønna, Arnt E.; Raastad, Truls; Hallén, Jostein; Norheim, Frode; Drevon, Christian A.; Romacho, Tania; Eckardt, Kristin; Eckel, Juergen (Journal article; Peer reviewed, 2013-09-11)
      Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves ...
    • Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise 

      Gjevestad, Gyrd O.; Hamarsland, Håvard; Raastad, Truls; Ottestad, Inger; Christensen, Jacob J.; Eckardt, Kristin; Drevon, Christian A.; Biong, Anne S.; Ulven, Stine M.; Holven, Kirsten B. (Journal article; Peer reviewed, 2017-03-03)
      Background: High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expression ...
    • Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines 

      Pourteymour, Shirin; Eckardt, Kristin; Holen, Torgeir; Langleite, Torgrim Mikal; Lee, Sindre; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A.; Hjorth, Marit (Journal article; Peer reviewed, 2017-01)
      Objective: Skeletal muscle is an important secretory organ, producing and releasing numerous myokines, which may be involved in mediating beneficial health effects of physical activity. More than 100 myokines have been ...
    • Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells 

      Raschke, Silja; Eckardt, Kristin; Holven, Kirsten Bjørklund; Jensen, Jørgen; Eckel, Jürgen (Journal article; Peer reviewed, 2013-04-24)
      Proteins secreted by skeletal muscle, so called myokines, have been shown to affect muscle physiology and additionally exert systemic effects on other tissues and organs. Although recent profiling studies have identified ...
    • The effect of acute and long‐term physical activity on extracellular matrix and serglycin in human skeletal muscle 

      Hjorth, Marit; Norheim, Frode; Meen, Astri Jeanette; Pourteymour, Shirin; Lee, Sindre; Holen, Torgeir; Jensen, Jørgen; Birkeland, Kåre I.; Martinov, Vladimir Nikolkaev; Langleite, Torgrim Mikal; Eckardt, Kristin; Drevon, Christian A.; Kolset, Svein Olav (Journal article; Peer reviewed, 2015-08-19)
      Remodeling of extracellular matrix (ECM), including regulation of proteoglycans in skeletal muscle can be important for physiological adaptation to exercise. To investigate the effects of acute and long‐term exercise on ...