• GDF15 provides an endocrine signal of nutritional stress in mice and humans 

      Patel, Satish; Álvarez-Guaita, Anna; Melvin, Audrey; Rimmington, Debra; Dattilo, Alessia; Miedzybrodzka, Emily L.; Cimino, Irene; Maurin, Anne-Catherine; Roberts, Geoffrey P.; Meek, Claire L.; Virtue, Samuel; Sparks, Lauren M.; Parsons, Stephanie A.; Redman, Leanne M.; Bray, George A.; Liou, Alice P.; Woods, Rachel M.; Parry, Sion A.; Jeppesen, Per Bendix; Kolnes, Anders Jensen; Harding, Heather P.; Ron, David; Vidal-Puig, Antonio; Reimann, Frank; Gribble, Fiona M.; Hulston, Carl J.; Farooqi, I. Sadaf; Fafournoux, Pierre; Smith, Steven R.; Jensen, Jørgen; Breen, Danna; Wu, Zhidan; Zhang, Bei B.; Coll, Anthony P.; Savage, David B.; O'Rahilly, Stephen (Peer reviewed; Journal article, 2019)
      GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological ...
    • The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise 

      Jensen, Jørgen; Rustad, Per Inge; Kolnes, Anders Jensen; Lai, Yu-Chiang (Journal article; Peer reviewed, 2011-12-30)
      Glycogen is the storage form of carbohydrates in mammals. In humans the majority of glycogen is stored in skeletal muscles (∼500 g) and the liver (∼100 g). Food is supplied in larger meals, but the blood glucose concentration ...