• GDF15 provides an endocrine signal of nutritional stress in mice and humans 

      Patel, Satish; Álvarez-Guaita, Anna; Melvin, Audrey; Rimmington, Debra; Dattilo, Alessia; Miedzybrodzka, Emily L.; Cimino, Irene; Maurin, Anne-Catherine; Roberts, Geoffrey P.; Meek, Claire L.; Virtue, Samuel; Sparks, Lauren M.; Parsons, Stephanie A.; Redman, Leanne M.; Bray, George A.; Liou, Alice P.; Woods, Rachel M.; Parry, Sion A.; Jeppesen, Per Bendix; Kolnes, Anders Jensen; Harding, Heather P.; Ron, David; Vidal-Puig, Antonio; Reimann, Frank; Gribble, Fiona M.; Hulston, Carl J.; Farooqi, I. Sadaf; Fafournoux, Pierre; Smith, Steven R.; Jensen, Jørgen; Breen, Danna; Wu, Zhidan; Zhang, Bei B.; Coll, Anthony P.; Savage, David B.; O'Rahilly, Stephen (Peer reviewed; Journal article, 2019)
      GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological ...
    • Truncation of Pik3r1 causes severe insulin resistance uncoupled from obesity and dyslipidaemia by increased energy expenditure 

      Kwok, Albert; Zvetkova, Ilona; Virtue, Samuel; Luijten, Ineke; Huang-Doran, Isabel; Tomlinson, Patsy; Bulger, David A.; West, James; Murfitt, Steven; Griffin, Julian; Alam, Rafeah; Hart, Daniel; Knox, Rachel; Voshol, Peter; Vidal-Puig, Antonio; Jensen, Jørgen; O'Rahilly, Stephen; Semple, Robert K. (Peer reviewed; Journal article, 2020)
      Objective: Insulin signalling via phosphoinositide 3-kinase (PI3K) requires PIK3R1-encoded regulatory subunits. C-terminal PIK3R1 mutations cause SHORT syndrome, as well as lipodystrophy and insulin resistance (IR), ...