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dc.contributor.authorSteene-Johannessen, Jostein
dc.contributor.authorKolle, Elin
dc.contributor.authorReseland, Janne E.
dc.contributor.authorAnderssen, Sigmund A.
dc.contributor.authorAndersen, Lars Bo
dc.date.accessioned2011-08-19T07:00:02Z
dc.date.available2011-08-19T07:00:02Z
dc.date.issued2010
dc.identifierSeksjon for idrettsmedisinske fag / Department of Sports Medicine
dc.identifier.citationInternational Journal of Pediatric Obesity. 2010, 5(4), 313-319en_US
dc.identifier.issn1747-7166
dc.identifier.urihttp://hdl.handle.net/11250/170869
dc.descriptionI Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på www.informaworld.com: http://dx.doi.org/10.3109/17477160903497035 / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The original publication is available at www.informaworld.com: http://dx.doi.org/10.3109/17477160903497035en_US
dc.description.abstractObjectives. To examine markers of infl ammation in 9- and 15-year-olds with high waist circumference and compare these with controls, and to examine the relationships between infl ammatory markers and cardiovascular disease (CVD) risk factors. Methods. Cross-sectional analysis of data from 2 299 Norwegian 9- and 15-year-olds participating in the “Physical activity among Norwegian Children Study”. In each sex and age group, the 10 participants with the highest waist circumference (HW) were selected (n 40) for analyses, and a random sample of 40 participants within the same groups were included as controls. Infl ammatory markers included C-reactive protein (CRP), leptin, adiponectin, plasminogen activator inhibitor-1 (PAI-1), tumor necrosis factor-α (TNF-α), hepatocyte growth factor (HGF), resistin and interleukin-6 (IL-6). The CVD risk factors included blood pressure, glucose, insulin, triglycerides and high density lipoprotein cholesterol. Results. HW participants had elevated levels of CRP (mean difference 1.50 mg/l; 95% confi dence interval [CI] 0.33 to 2.66), PAI-1 (mean difference 13.3 ng/ml; 95% CI 4.1 to 22.5) and HGF (mean difference 0.29 ng/ml; 95% CI 0.07 to 0.51) compared with controls. All CVD risk factors differed between the HW group and controls. The CVD risk factors were not associated with TNFα or IL-6, but CRP, HGF and PAI-1 were related to the metabolic risk score. Conclusions. Low grade systemic infl ammation is already present in youth with high waist circumference. CRP, HGF and PAI-1 may be related to the adverse overall metabolic risk profi le observed in these children and adolescents.en_US
dc.language.isoengen_US
dc.publisherTaylor & Francisen_US
dc.subjectadolescenten_US
dc.subjectbiological markersen_US
dc.subjectc-reactive proteinen_US
dc.subjectcardiovascular diseasesen_US
dc.subjectepidemiologyen_US
dc.subjectcase-control studiesen_US
dc.subjectchilden_US
dc.subjectcross-sectional studiesen_US
dc.subjectfemaleen_US
dc.subjecthepatocyte growth factoren_US
dc.subjecthumansen_US
dc.subjectinflammationen_US
dc.subjectblooden_US
dc.subjectmaleen_US
dc.subjectNorwayen_US
dc.subjectobesityen_US
dc.subjectphysiopathologyen_US
dc.subjectplasminogen activator inhibitor 1en_US
dc.subjectrisk factorsen_US
dc.subjectwaist circumferenceen_US
dc.subjectc-reactive proteinen_US
dc.subjectmetabolismen_US
dc.subjectbiological markersen_US
dc.titleWaist circumference is related to low-grade inflammation in youthen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750::Pediatrics: 760en_US
dc.source.pagenumber313-319en_US


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