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dc.contributor.authorGejl, Anne Kær
dc.contributor.authorEnevold, Christian
dc.contributor.authorBugge, Anna
dc.contributor.authorAndersen, Marianne Skovsager
dc.contributor.authorNielsen, Claus Henrik
dc.contributor.authorAndersen, Lars Bo
dc.date.accessioned2020-04-24T09:02:06Z
dc.date.available2020-04-24T09:02:06Z
dc.date.created2019-08-23T11:41:38Z
dc.date.issued2019
dc.identifier.citationScientific Reports. 2019, 9, 9655.en_US
dc.identifier.issn2045-2322
dc.identifier.urihttps://hdl.handle.net/11250/2652379
dc.descriptionThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. Te images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.en_US
dc.description.abstractThe aims of the study were to clarify the impact of storage time and centrifugation strategy on brain-derived neurotrophic factor (BDNF) levels in human serum and plasma samples. In addition, we analyzed associations between BDNF levels, cardiorespiratory ftness and waist circumference. Seventeen healthy males (25.2 (4.1) years) were included in the study. Blood samples were drawn after an overnight fast and treated to diferent protocols, varying in time before centrifugation and centrifugation strategy. BDNF was analyzed in serum, normal plasma (NP) and platelet-poor plasma (PPP). Also, waist circumference and cardiorespiratory ftness were measured. A large increase was observed in serum BDNF levels during the frst hour of clotting. BDNF in NP correlated with PPP, whereas no correlations were found between BDNF in serum and plasma. Though not statistical signifcant, correlations between ftness and BDNF in serum changed from positive at 30min. to negative when clotting time was ≥60min. In conclusion, BDNF levels in serum were afected by clotting time, whereas BDNF levels in plasma were infuenced by centrifugation strategy. Importantly, BDNF in serum and plasma appears to refect two diferent pools of BDNF. The biological relevance of the velocity of BDNF release during clotting and its dependence upon ftness must be investigated further.en_US
dc.language.isoengen_US
dc.subjectblood proteins
dc.subjectbiological techniques
dc.subjectbiomarkers
dc.titleAssociations between serum and plasma brain-derived neurotrophic factor and influence of storage time and centrifugation strategyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s) 2019en_US
dc.source.pagenumber9en_US
dc.source.volume9en_US
dc.source.journalScientific Reportsen_US
dc.identifier.doi10.1038/s41598-019-45976-5
dc.identifier.cristin1718247
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sports Medicineen_US
cristin.unitcode150,34,0,0
cristin.unitnameSeksjon for idrettsmedisinske fag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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