dc.contributor.author | Stamatakis, Emmanuel | |
dc.contributor.author | Gale, Joanne | |
dc.contributor.author | Bauman, Adrian | |
dc.contributor.author | Ekelund, Ulf | |
dc.contributor.author | Hamer, Mark | |
dc.contributor.author | Ding, Ding | |
dc.date.accessioned | 2020-04-24T09:23:05Z | |
dc.date.available | 2020-04-24T09:23:05Z | |
dc.date.created | 2019-06-06T13:43:38Z | |
dc.date.issued | 2019 | |
dc.identifier.citation | Journal of the American College of Cardiology. 2019, 73(16), 2062-2072. | en_US |
dc.identifier.issn | 0735-1097 | |
dc.identifier.uri | https://hdl.handle.net/11250/2652383 | |
dc.description | This is an open access article under theCC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). | en_US |
dc.description.abstract | Background: It is unclear what level of moderate to vigorous intensity physical activity (MVPA) offsets the health risks of sitting.
Objectives: The purpose of this study was to examine the joint and stratified associations of sitting and MVPA with all-cause and cardiovascular disease (CVD) mortality, and to estimate the theoretical effect of replacing sitting time with physical activity, standing, and sleep.
Methods: A longitudinal analysis of the 45 and Up Study calculated the multivariable-adjusted hazard ratios (HRs) of sitting for each sitting-MVPA combination group and within MVPA strata. Isotemporal substitution modeling estimated the per-hour HR effects of replacing sitting.
Results: A total of 8,689 deaths (1,644 due to CVD) occurred among 149,077 participants over an 8.9-year (median) follow-up. There was a statistically significant interaction between sitting and MVPA only for all-cause mortality. Sitting time was associated with both mortality outcomes in a nearly dose-response manner in the least active groups reporting <150 MVPA min/week. For example, among those reporting no MVPA, the all-cause mortality HR comparing the most sedentary (>8 h/day) to the least sedentary (<4 h/day) groups was 1.52 (95% confidence interval: 1.13 to 2.03). There was inconsistent and weak evidence for elevated CVD and all-cause mortality risks with more sitting among those meeting the lower (150 to 299 MVPA min/week) or upper (≥300 MVPA min/week) limits of the MVPA recommendation. Replacing sitting with walking and MVPA showed stronger associations among high sitters (>6 sitting h/day) where, for example, the per-hour CVD mortality HR for sitting replaced with vigorous activity was 0.36 (95% confidence interval: 0.17 to 0.74).
Conclusions: Sitting is associated with all-cause and CVD mortality risk among the least physically active adults; moderate-to-vigorous physical activity doses equivalent to meeting the current recommendations attenuate or effectively eliminate such associations. | en_US |
dc.language.iso | eng | en_US |
dc.subject | cardiovascular disease | en_US |
dc.subject | epidemiology | en_US |
dc.subject | exercise | en_US |
dc.subject | mortality | en_US |
dc.subject | physical activity | en_US |
dc.subject | sedentary behavior | en_US |
dc.title | Sitting Time, Physical Activity, and Risk of Mortality in Adults | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2019 The Authors. | en_US |
dc.source.pagenumber | 2062-2072 | en_US |
dc.source.volume | 73 | en_US |
dc.source.journal | Journal of the American College of Cardiology | en_US |
dc.source.issue | 16 | en_US |
dc.identifier.doi | 10.1016/j.jacc.2019.02.031 | |
dc.identifier.cristin | 1703183 | |
dc.description.localcode | Seksjon for idrettsmedisinske fag / Department of Sports Medicine | en_US |
cristin.unitcode | 150,34,0,0 | |
cristin.unitname | Seksjon for idrettsmedisinske fag | |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 2 | |