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dc.contributor.authorTarp, Jakob
dc.contributor.authorStøle, Andreas
dc.contributor.authorBlond, Kim
dc.contributor.authorGrøntved, Anders
dc.date.accessioned2020-04-29T09:21:07Z
dc.date.available2020-04-29T09:21:07Z
dc.date.created2019-07-04T15:27:30Z
dc.date.issued2019
dc.identifier.citationDiabetologia. 2019, 62(7), 1129-1142.en_US
dc.identifier.issn0012-186X
dc.identifier.urihttps://hdl.handle.net/11250/2652888
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.en_US
dc.description.abstractAims/hypothesis The study aimed to quantitatively summarise the dose–response relationships between cardiorespiratory fitness and muscular strength on the one hand and risk of type 2 diabetes on the other and estimate the hypothetical benefits associated with population-wide changes in the distribution of fitness. Methods We performed a systematic review with meta-analysis. The PubMed and EMBASE electronic databases were searched from inception dates to 12 December 2018 for cohort studies examining the association of cardiorespiratory fitness or muscular strength with risk of incident type 2 diabetes in adults. The quality of included studies was evaluated using the Newcastle–Ottawa Scale. Results Twenty-two studies of cardiorespiratory fitness and 13 studies of muscular strength were included in the systematic review with both exposures having ten estimates available for the primary adiposity- or body size-controlled meta-analysis. In random-effects meta-analysis including 40,286 incident cases of type 2 diabetes in 1,601,490 participants, each 1 metabolic equivalent (MET) higher cardiorespiratory fitness was associated with an 8% (95% CI 6%, 10%) lower RR of type 2 diabetes. The association was linear throughout the examined spectrum of cardiorespiratory fitness. In 39,233 cases and 1,713,468 participants each 1 SD higher muscular strength was associated with a 13% (95% CI 6%, 19%) lower RR of type 2 diabetes. We estimated that 4% to 21% of new annual cases of type 2 diabetes among 45–64-year-olds could be prevented by feasible and plausible population cardiorespiratory fitness changes. Conclusions/interpretation Relatively small increments in cardiorespiratory fitness and muscle strength were associated with clinically meaningful reductions in type 2 diabetes risk with indication of a linear dose–response relationship for cardiorespiratory fitness.en_US
dc.language.isoengen_US
dc.subjectepidemiologyen_US
dc.subjectfitnessen_US
dc.subjectmeta-analysisen_US
dc.subjectphysical activityen_US
dc.subjectpublic healthen_US
dc.subjectsystematic reviewen_US
dc.subjecttype 2 diabetesen_US
dc.titleCardiorespiratory fitness, muscular strength and risk of type 2 diabetes: a systematic review and meta-analysisen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s) 2019en_US
dc.source.pagenumber1129-1142en_US
dc.source.volume62en_US
dc.source.journalDiabetologiaen_US
dc.source.issue7en_US
dc.identifier.doi10.1007/s00125-019-4867-4
dc.identifier.cristin1710197
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sports Medicineen_US
cristin.unitcode150,34,0,0
cristin.unitnameSeksjon for idrettsmedisinske fag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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