Show simple item record

dc.contributor.authorWijndaele, Katrien
dc.contributor.authorWhite, Thomas
dc.contributor.authorAndersen, Lars Bo
dc.contributor.authorBugge, Anna
dc.contributor.authorKolle, Elin
dc.contributor.authorNorthstone, Kate
dc.contributor.authorWedderkopp, Niels
dc.contributor.authorRied-Larsen, Mathias
dc.contributor.authorKriemler, Susi
dc.contributor.authorPage, Angie S.
dc.contributor.authorPuder, Jardena J.
dc.contributor.authorReilly, John J.
dc.contributor.authorSardinha, Luis B.
dc.contributor.authorvan Sluijs, Esther M.F.
dc.contributor.authorSharp, Stephen J.
dc.contributor.authorBrage, Søren
dc.contributor.authorEkelund, Ulf
dc.date.accessioned2020-05-14T09:44:07Z
dc.date.available2020-05-14T09:44:07Z
dc.date.created2020-01-10T10:02:43Z
dc.date.issued2019
dc.identifier.citationInternational Journal of Behavioral Nutrition and Physical Activity. 2019, 16, 96.en_US
dc.identifier.issn1479-5868
dc.identifier.urihttps://hdl.handle.net/11250/2654412
dc.descriptionThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.en_US
dc.description.abstractBackground: Evidence on the association between sitting for extended periods (i.e. prolonged sedentary time (PST)) and cardio-metabolic health is inconsistent in children. We aimed to estimate the differences in cardiometabolic health associated with substituting PST with non-prolonged sedentary time (non-PST), light (LIPA) or moderate-to-vigorous physical activity (MVPA) in children. Methods: Cross-sectional data from 14 studies (7 countries) in the International Children’s Accelerometry Database (ICAD, 1998–2009) was included. Accelerometry in 19,502 participants aged 3–18 years, together with covariate and outcome data, was pooled and harmonized. Iso-temporal substitution in linear regression models provided beta coefficients (95%CI) for substitution of 1 h/day PST (sedentary time accumulated in bouts > 15 min) with non-PST, LIPA or MVPA, for each study, which were meta-analysed. Results: Modelling substitution of 1 h/day of PST with non-PST suggested reductions in standardized BMI, but estimates were > 7-fold greater for substitution with MVPA (− 0.44 (− 0.62; − 0.26) SD units). Only reallocation by MVPA was beneficial for waist circumference (− 3.07 (− 4.47; − 1.68) cm), systolic blood pressure (− 1.53 (− 2.42; − 0.65) mmHg) and clustered cardio-metabolic risk (− 0.18 (− 0.3; − 0.1) SD units). For HDL-cholesterol and diastolic blood pressure, substitution with LIPA was beneficial; however, substitution with MVPA showed 5-fold stronger effect estimates (HDL-cholesterol: 0.05 (0.01; 0.10) mmol/l); diastolic blood pressure: − 0.81 (− 1.38; − 0.24) mmHg). Conclusions: Replacement of PST with MVPA may be the preferred scenario for behaviour change, given beneficial associations with a wide range of cardio-metabolic risk factors (including adiposity, HDL-cholesterol, blood pressure and clustered cardio-metabolic risk). Effect estimates are clinically relevant (e.g. an estimated reduction in waist circumference of ≈1.5 cm for 30 min/day replacement). Replacement with LIPA could be beneficial for some of these risk factors, however with substantially lower effect estimates.en_US
dc.language.isoengen_US
dc.subjectICADen_US
dc.subjectALSPACen_US
dc.subjectprolonged sittingen_US
dc.subjectcardio-metabolicen_US
dc.subjectiso-temporalen_US
dc.subjectphysical activityen_US
dc.titleSubstituting prolonged sedentary time and cardiovascular risk in children and youth: a meta-analysis within the International Children’s Accelerometry database (ICAD)en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s). 2019en_US
dc.source.pagenumber1-10en_US
dc.source.volume16:96en_US
dc.source.journalInternational Journal of Behavioral Nutrition and Physical Activityen_US
dc.identifier.doi10.1186/s12966-019-0858-6
dc.identifier.cristin1770009
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sports Medicineen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record