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dc.contributor.authorAas, Sigve Nyvik
dc.contributor.authorBreit, Markus
dc.contributor.authorKarsrud, Stian
dc.contributor.authorAase, Ole Jølle
dc.contributor.authorRognlien, Simen Helset
dc.contributor.authorCumming, Kristoffer Toldnes
dc.contributor.authorReggiani, Carlo
dc.contributor.authorSeynnes, Olivier R.
dc.contributor.authorRossi, Andrea
dc.contributor.authorToniolo, Luana
dc.contributor.authorRaastad, Truls
dc.date.accessioned2020-10-20T13:23:34Z
dc.date.available2020-10-20T13:23:34Z
dc.date.created2020-09-01T09:56:47Z
dc.date.issued2020
dc.identifier.citationJournal of Cachexia, Sarcopenia and Muscle. 2020, 11(3), 663-677.en_US
dc.identifier.issn2190-5991
dc.identifier.urihttps://hdl.handle.net/11250/2683954
dc.descriptionThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_US
dc.description.abstractBackground The improvement in muscle strength generally exceeds the increase in muscle size following strength training in frail elderly, highlighting the complex aetiology of strength deficit in aging. The aim of this study was to investigate the effect of heavy‐load strength training on a broad number of factors related to specific strength in frail elderly. Methods Thirty‐four frail elderly men (n = 18) and women (n = 16) aged 67 to 98 (86 ± 7 years) were randomized to either a group performing strength training twice a week for 10 weeks (ST) or a non‐exercising control group (CON). Knee extensor muscle strength was tested as one‐repetition maximum (1RM) and isometric maximal voluntary contraction (MVC) torque. Muscle activation was assessed by the interpolated twitch technique, and muscle density [mean Hounsfield units (HU)] and intermuscular adipose tissue (IMAT) by computed tomography scans of the quadriceps femoris. Muscle biopsies from the vastus lateralis were obtained to investigate changes in intramyocellular lipids and single‐fibre specific tension. Results In ST, knee extension 1RM and MVC improved by 17 and 7%, respectively. Muscle cross‐sectional area of the quadriceps femoris increased by 7%, accompanied by a 4% increase of muscle density. No changes in IMAT, voluntary activation level, single‐fibre specific tension, or lipid content were observed. Conclusions In contrast to several previous reports, the improvements in isometric muscle strength and muscle area were in good agreement in the present study. The training‐induced increase in muscle density was not due to changes in skeletal muscle lipid content. Instead, the increase in muscle density may reflect increased packing of contractile material or simply an increased ratio of muscle tissue relative to IMAT.en_US
dc.language.isoengen_US
dc.subjectresistance exerciseen_US
dc.subjectsarcopeniaen_US
dc.subjectspecific strengthen_US
dc.subjectmuscle attenuationen_US
dc.subjectlipid contenten_US
dc.titleMusculoskeletal adaptations to strength training in frail elderly: A matter of quantity or quality?en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 The Authorsen_US
dc.source.pagenumber663-677en_US
dc.source.volume11en_US
dc.source.journalJournal of Cachexia, Sarcopenia and Muscleen_US
dc.source.issue3en_US
dc.identifier.doi10.1002/jcsm.12543
dc.identifier.cristin1826379
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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