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dc.contributor.authorAreta, José
dc.contributor.authorIraki, Juma
dc.contributor.authorOwens, Daniel J.
dc.contributor.authorJoanisse, Sophie
dc.contributor.authorPhilp, Andrew
dc.contributor.authorMorton, James P.
dc.contributor.authorHallén, Jostein
dc.date.accessioned2021-01-29T10:11:38Z
dc.date.available2021-01-29T10:11:38Z
dc.date.created2020-11-06T14:30:38Z
dc.date.issued2020
dc.identifier.citationExperimental Physiology. 2020, 105(10), 1778-1791.en_US
dc.identifier.issn0958-0670
dc.identifier.urihttps://hdl.handle.net/11250/2725316
dc.descriptionThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractTraining with low carbohydrate availability (LCHO) has been shown to acutely enhance endurance training skeletal muscle response, but the concomitant energy deficit (ED) in LCHO interventions has represented a confounding factor in past research. This study aimed at determining if achieving energy balance with high fat (EB‐HF) acutely enhances the adaptive response in LCHO compared to ED with low fat (ED‐LF). In a crossover design, nine well‐trained males completed a ‘sleep‐low’ protocol: on day 1 they cycled to deplete muscle glycogen while reaching a set energy expenditure (30 kcal (kg of fat free mass (FFM))−1). Post‐exercise, low carbohydrate, protein‐matched meals completely (EB‐HF, 30 kcal (kg FFM)−1) or partially (ED‐LF, 9 kcal (kg FFM)−1) replaced the energy expended, with the majority of energy derived from fat in EB‐HF. In the morning of day 2, participants exercised fasted, and skeletal muscle and blood samples were collected and a carbohydrate–protein drink was ingested at 0.5 h recovery. Muscle glycogen showed no treatment effect (P < 0.001) and decreased from 350 ± 98 to 192 ± 94 mmol (kg dry mass)−1 between rest and 0.5 h recovery. Phosphorylation status of the mechanistic target of rapamycin and AMP‐activated protein kinase pathway proteins showed only time effects. mRNA expression of p53 increased after exercise (P = 0.005) and was higher in ED‐LF at 3.5 h compared to EB‐HF (P = 0.027). Plasma glucose and insulin area under the curve (P < 0.04) and peak values (P ≤ 0.05) were higher in EB‐HF after the recovery drink. Achieving energy balance with a high‐fat meal in a ‘train‐low’ (‘sleep‐low’) model did not enhance markers of skeletal muscle adaptation and impaired glycaemia in response to a recovery drink following training in the morning.en_US
dc.language.isoengen_US
dc.subjectenduranceen_US
dc.subjectenergy availabilityen_US
dc.subjecthigh‐fat feedingen_US
dc.subjectmuscle glycogenen_US
dc.subjecttrain lowen_US
dc.titleAchieving energy balance with a high‐fat meal does not enhance skeletal muscle adaptation and impairs glycaemic response in a sleep‐low training modelen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 The Authors.en_US
dc.source.pagenumber1778-1791en_US
dc.source.volume105en_US
dc.source.journalExperimental Physiologyen_US
dc.source.issue10en_US
dc.identifier.doi10.1113/EP088795
dc.identifier.cristin1845686
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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