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dc.contributor.authorBjørke, Ann Christin Helgesen
dc.contributor.authorRaastad, Truls
dc.contributor.authorBerntsen, Sveinung
dc.date.accessioned2021-01-29T10:17:08Z
dc.date.available2021-01-29T10:17:08Z
dc.date.created2020-08-13T14:08:55Z
dc.date.issued2020
dc.identifier.citationPLOS ONE. 2020, 15 (6), Artikkel e0234507.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/2725320
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.description.abstractIntroduction: Maximal oxygen uptake () is a measure of cardiorespiratory fitness often used to monitor changes in fitness during and after treatment in cancer patients. There is, however, limited knowledge in how criteria verifying work for patients newly diagnosed with cancer. Therefore, the aim of this study was to describe the prevalence of fulfillment of typical criteria verifying and to investigate the associations between the criteria and the test leader’s evaluation whether a test was performed “to exhaustion”. An additional aim was to establish new cut-points within the associated criteria. Methods: From the Phys-Can randomized controlled trial, 535 patients (59 ±12 years) newly diagnosed with breast (79%), prostate (17%) or colorectal cancer (4%) performed an incremental test on a treadmill. The test was performed before starting (neo-)adjuvant treatment and an exercise intervention. Fulfillment of different cut-points within typical criteria verifying was described. The dependent key variables included in the initial bivariate analysis were achievement of a plateau, peak values for maximal heart rate, respiratory exchange ratio (RER), the patients’ rating of perceived exertion on Borg’s scale6-20 and peak breathing frequency (fR). A receiver operating characteristic analysis was performed to establish cut-points for variables associated with the test leader’s evaluation. Last, a cross-validation of the cut-points found in the receiver operating characteristic analysis was performed on a comparable sample of cancer patients (n = 80). Results: The criteria RERpeak (<0.001), Borg’s RPE (<0.001) and fR peak (p = 0.018) were associated with the test leader’s evaluation of whether a test was defined as “to exhaustion”. The cut-points that best predicted the test leader’s evaluation were RER ≥ 1.14, RPE ≥ 18 and fR ≥ 40. Maximal heart rate and plateau was not associated with the test leader’s evaluation. Conclusion: We recommend a focus on RER (in the range between ≥1.1 and ≥1.15) and RPE (≥17 or ≥18) in addition to the test leader’s evaluation. Additionally, a fR peak of ≥40 breaths/min may be a cut-point to help the test leader evaluate the degree of exhaustion. However, more research is needed to verify our findings, and to investigate how these criteria will work within a population that are undergoing or finished with cancer treatment.en_US
dc.language.isoengen_US
dc.subjectcancer treatmenten_US
dc.subjectcancers and neoplasmsen_US
dc.subjectexerciseen_US
dc.subjectcolorectal canceren_US
dc.subjectcancer detection and diagnosisen_US
dc.subjectprostate canceren_US
dc.subjectbreast canceren_US
dc.subjectphysical activityen_US
dc.titleCriteria for the determination of maximal oxygen uptake in patients newly diagnosed with cancer: Baseline data from the randomized controlled trial of physical training and cancer (Phys-Can)en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2020 Bjørke et al.en_US
dc.source.pagenumber18en_US
dc.source.volume15en_US
dc.source.journalPLOS ONEen_US
dc.source.issue6en_US
dc.identifier.doi10.1371/journal.pone.0234507
dc.identifier.cristin1823190
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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