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dc.contributor.authorTarp, Jakob
dc.contributor.authorHansen, Bjørge Hermann
dc.contributor.authorFagerland, Morten
dc.contributor.authorSteene-Johannessen, Jostein
dc.contributor.authorAnderssen, Sigmund Alfred
dc.contributor.authorEkelund, Ulf
dc.date.accessioned2021-02-10T10:23:18Z
dc.date.available2021-02-10T10:23:18Z
dc.date.created2020-08-24T16:16:44Z
dc.date.issued2020
dc.identifier.citationInternational Journal of Behavioral Nutrition and Physical Activity. 2020, 17, Artikkel 39.en_US
dc.identifier.issn1479-5868
dc.identifier.urihttps://hdl.handle.net/11250/2727137
dc.descriptionThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.en_US
dc.description.abstractBackground: Observational studies linking physical activity with mortality are susceptible to reverse causation bias from undiagnosed and prevalent diseases. Researchers often attempt to deal with reverse causation bias by excluding deaths occurring within the first 1 or 2 years from the analysis, but it is unclear if excluding deaths within this time-frame is sufficient to remove bias. Methods: We examined associations between total and intensity-specific physical activity and sedentary time with all-cause mortality in a prospective cohort of 3542 individuals from the 2003-2006 NHANES cycles. In order to yield measures of association hypothesized as minimally influenced by reverse causation bias the primary analysis excluded individuals with < 5 years of follow-up. Accelerometer-measured physical activity was linked with recently updated vital status from the National Death Index with a median follow-up of 10.8 years. Results: Hazard ratios (95% confidence intervals) were 0.74 (0.53, 1.04), 0.52 (0.37, 0.73), and 0.61 (0.38, 1.01) for ascending quartiles of total physical activity against the least active reference. Hazard ratios for ascending moderate-to-vigorous physical activity quartiles against the reference were 0.67 (0.47, 1.96), 0.67 (0.47, 0.95), and 0.68 (0.39, 1.18). Associations for light intensity physical activity and sedentary time were smaller in magnitude and all confidence intervals included unity. Total activity and moderate-to-vigorous physical activity hazard ratios from analyses only excluding deaths within the first 2 years were inflated by 13 and 26% relative to analysis restricted to ≥5 years of follow-up. Conclusions: The pattern of associations suggested total physical activity and moderate-to-vigorous physical activity were associated with lower mortality after more than 10 years of follow-up and excluding the first 5 years of observation time to minimize the impact of reverse causation bias. Excluding deaths within the first 2 years appeared insufficient to minimize the impact of reserve causation bias.en_US
dc.language.isoengen_US
dc.subjectcohort studyen_US
dc.subjectepidemiologyen_US
dc.subjectexerciseen_US
dc.subjectleisure activityen_US
dc.titleAccelerometer-measured physical activity and sedentary time in a cohort of US adults followed for up to 13 years: The influence of removing early follow-up on associations with mortalityen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s). 2020.en_US
dc.source.pagenumber8en_US
dc.source.volume17en_US
dc.source.journalInternational Journal of Behavioral Nutrition and Physical Activityen_US
dc.identifier.doi10.1186/s12966-020-00945-4
dc.identifier.cristin1824885
dc.description.localcodeInstitutt for idrettsmedisinske fag / Department of Sports Medicineen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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