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dc.contributor.authorEkelund, Ulf
dc.contributor.authorTarp, Jakob
dc.contributor.authorFagerland, Morten Wang
dc.contributor.authorSteene-Johannessen, Jostein
dc.contributor.authorHansen, Bjørge Herman
dc.contributor.authorJefferis, Barbara
dc.contributor.authorWhincup, Peter H.
dc.contributor.authorDiaz, Keith M.
dc.contributor.authorHooker, Steven
dc.contributor.authorHoward, Virginia J.
dc.contributor.authorChernofsky, Ariel
dc.contributor.authorLarson, Martin G.
dc.contributor.authorSpartano, Nicole
dc.contributor.authorVasan, Ramachandran S.
dc.contributor.authorDohrn, Ing-Mari
dc.contributor.authorHagströmer, Maria
dc.contributor.authorEdwardson, Charlotte
dc.contributor.authorYates, Thomas
dc.contributor.authorShiroma, Eric
dc.contributor.authorDempsey, Paddy
dc.contributor.authorWijndaele, Katrien
dc.contributor.authorAnderssen, Sigmund Alfred
dc.contributor.authorLee, I-Min
dc.date.accessioned2021-03-04T13:40:27Z
dc.date.available2021-03-04T13:40:27Z
dc.date.created2021-01-06T14:04:54Z
dc.date.issued2020
dc.identifier.citationBritish Journal of Sports Medicine. 2020, 54(24), 1499-1507.en_US
dc.identifier.issn0306-3674
dc.identifier.urihttps://hdl.handle.net/11250/2731683
dc.descriptionThis is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.en_US
dc.description.abstractObjectives: To examine the joint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality. Methods: We conducted a harmonised meta-analysis including nine prospective cohort studies from four countries. 44 370 men and women were followed for 4.0 to 14.5 years during which 3451 participants died (7.8% mortality rate). Associations between different combinations of moderate-to-vigorous intensity physical activity (MVPA) and sedentary time were analysed at study level using Cox proportional hazards regression analysis and summarised using random effects meta-analysis. Results: Across cohorts, the average time spent sedentary ranged from 8.5 hours/day to 10.5 hours/day and 8 min/day to 35 min/day for MVPA. Compared with the referent group (highest physical activity/lowest sedentary time), the risk of death increased with lower levels of MVPA and greater amounts of sedentary time. Among those in the highest third of MVPA, the risk of death was not statistically different from the referent for those in the middle (16%; 95% CI 0.87% to 1.54%) and highest (40%; 95% CI 0.87% to 2.26%) thirds of sedentary time. Those in the lowest third of MVPA had a greater risk of death in all combinations with sedentary time; 65% (95% CI 1.25% to 2.19%), 65% (95% CI 1.24% to 2.21%) and 263% (95% CI 1.93% to 3.57%), respectively. Conclusion: Higher sedentary time is associated with higher mortality in less active individuals when measured by accelerometry. About 30–40 min of MVPA per day attenuate the association between sedentary time and risk of death, which is lower than previous estimates from self-reported data.en_US
dc.language.isoengen_US
dc.subjectaccelerometeren_US
dc.subjectdeathen_US
dc.subjectmeta-analysisen_US
dc.subjectsedentaryen_US
dc.titleJoint associations of accelerometer-measured physical activity and sedentary time with all-cause mortality: A harmonised meta-analysis in more than 44 000 middle-aged and older individualsen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© Author(s) (or their employer(s)) 2020en_US
dc.source.pagenumber1499-1507en_US
dc.source.volume54en_US
dc.source.journalBritish Journal of Sports Medicineen_US
dc.source.issue24en_US
dc.identifier.doi10.1136/bjsports-2020-103270
dc.identifier.cristin1866369
dc.description.localcodeInstitutt for idrettsmedisinske fag / Department of Sports Medicineen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


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