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dc.contributor.authorMyrdal, Ole Henrik
dc.contributor.authorDiep, Phoi Phoi
dc.contributor.authorRuud, Ellen
dc.contributor.authorBrinch, Lorentz
dc.contributor.authorEdvardsen, Elisabeth
dc.contributor.authorKongerud, Johny
dc.contributor.authorLund, May-Brith
dc.contributor.authorSikkeland, Liv Ingunn Bjoner
dc.contributor.authorMassey, Richard J.
dc.date.accessioned2021-03-04T14:30:51Z
dc.date.available2021-03-04T14:30:51Z
dc.date.created2021-01-13T09:31:23Z
dc.date.issued2020
dc.identifier.citationSupportive Care in Cancer. 2021, 29(4), 1959-1967.en_US
dc.identifier.issn0941-4355
dc.identifier.urihttps://hdl.handle.net/11250/2731709
dc.descriptionThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder.en_US
dc.description.abstractPurpose: Survivors of allogeneic hematopoietic stem cell transplantation (allo-HSCT) are at risk for cardiopulmonary adverse events. Data on long-term effects on cardiorespiratory fitness are limited. To address the gap in knowledge, we aimed to determine peak oxygen uptake (V̇O2peak) and identify associations between cardiorespiratory fitness and clinical characteristics, self-reported physical activity, cardiac, and pulmonary function. Methods: In a nationwide, single-center cross-sectional study, 90 survivors [aged median (range) 35 (17–54) years, 56% females] were examined, 17 (6–26) years after allo-HSCT. Myeloablative conditioning comprised busulfan/cyclophosphamide or cyclophosphamide only. Methods included pulmonary function tests, echocardiography, and cardiopulmonary exercise test. Results: Chronic graft-versus-host disease (cGVHD) was found in 31% of the subjects, of whom 40% had bronchiolitis obliterans syndrome (BOS). Seventy-one percent of the survivors did not meet WHO recommendations for physical activity and 42% were overweight. Reduced gas diffusion (DLCO) and systolic ventricular dysfunction (LVEF) were found in 44% and 31%, respectively. For the group, mean (95% CI), V̇O2peak was 36.4 (34.7–38.0) mL/min/kg [89 (85–93)% of predicted]. V̇O2peak was low at 43%. Cardiopulmonary factors and deconditioning were equally common limitations for exercise. In a multiple linear regression model, low V̇O2peak was associated with low DLCO, low LVEF, BOS, overweight, and inactivity. Conclusion: Half of the survivors had reduced cardiorespiratory fitness median 17 years after allo-HSCT. Cardiopulmonary factors and deconditioning were equally common limitations to exercise. We encourage long-term cardiopulmonary monitoring of allo-HSCT survivors and targeted advice on modifiable lifestyle factors.en_US
dc.language.isoengen_US
dc.subjectallogeneic hematopoietic stem cell transplantationen_US
dc.subjectlong-term follow-upen_US
dc.subjectcardiorespiratory fitnessen_US
dc.subjectcardiac functionen_US
dc.subjectpulmonary functionen_US
dc.titleDeterminants of cardiorespiratory fitness in very long-term survivors of allogeneic hematopoietic stem cell transplantation: A national cohort studyen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© The Author(s) 2020en_US
dc.source.pagenumber1959-1967en_US
dc.source.volume29en_US
dc.source.journalSupportive Care in Canceren_US
dc.source.issue4en_US
dc.identifier.doi10.1007/s00520-020-05644-1
dc.identifier.cristin1870347
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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