Show simple item record

dc.contributor.authorDemmelmaier, Ingrid
dc.contributor.authorBrooke, Hannah L.
dc.contributor.authorHenriksson, Anna
dc.contributor.authorMazzoni, Anne-Sophie
dc.contributor.authorBjørke, Ann Christin Helgesen
dc.contributor.authorIgelström, Helena
dc.contributor.authorAx, Anna-Karin
dc.contributor.authorSjövall, Katarina
dc.contributor.authorHellbom, Maria
dc.contributor.authorPingel, Ronnie
dc.contributor.authorLindman, Henrik
dc.contributor.authorJohansson, Silvia
dc.contributor.authorVelikova, Galina
dc.contributor.authorRaastad, Truls
dc.contributor.authorBuffart, Laurien M.
dc.contributor.authorÅsenlöf, Pernilla
dc.contributor.authorAaronson, Neil K.
dc.contributor.authorGlimelius, Bengt
dc.contributor.authorNygren, Peter
dc.contributor.authorJohansson, Birgitta
dc.contributor.authorBörjeson, Sussanne
dc.contributor.authorBerntsen, Sveinung
dc.contributor.authorNordin, Karin
dc.date.accessioned2021-09-21T11:41:27Z
dc.date.available2021-09-21T11:41:27Z
dc.date.created2021-06-17T14:33:07Z
dc.date.issued2021
dc.identifier.citationScandinavian Journal of Medicine & Science in Sports. 2021, 31(5), 1144-1159.en_US
dc.identifier.issn0905-7188
dc.identifier.urihttps://hdl.handle.net/11250/2779864
dc.descriptionThis is an open access article under the terms of the Creative Commons Attribution-NonCommercial License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited and is not used for commercial purposes.en_US
dc.description.abstractExercise during cancer treatment improves cancer-related fatigue (CRF), but the importance of exercise intensity for CRF is unclear. We compared the effects of high- vs low-to-moderate-intensity exercise with or without additional behavior change support (BCS) on CRF in patients undergoing (neo-)adjuvant cancer treatment. This was a multicenter, 2x2 factorial design randomized controlled trial (Clinical Trials NCT02473003) in Sweden. Participants recently diagnosed with breast (n = 457), prostate (n = 97) or colorectal (n = 23) cancer undergoing (neo-)adjuvant treatment were randomized to high intensity (n = 144), low-to-moderate intensity (n = 144), high intensity with BCS (n = 144) or low-to-moderate intensity with BCS (n = 145). The 6-month exercise intervention included supervised resistance training and home-based endurance training. CRF was assessed by Multidimensional Fatigue Inventory (MFI, five subscales score range 4-20), and Functional Assessment of Chronic Illness Therapy-Fatigue scale (FACIT-F, score range 0-52). Multiple linear regression for main factorial effects was performed according to intention-to-treat, with post-intervention CRF as primary endpoint. Overall, 577 participants (mean age 58.7 years) were randomized. Participants randomized to high- vs low-to-moderate-intensity exercise had lower physical fatigue (MFI Physical Fatigue subscale; mean difference −1.05 [95% CI: −1.85, −0.25]), but the difference was not clinically important (ie <2). We found no differences in other CRF dimensions and no effect of additional BCS. There were few minor adverse events. For CRF, patients undergoing (neo-)adjuvant treatment for breast, prostate or colorectal cancer can safely exercise at high- or low-to-moderate intensity, according to their own preferences. Additional BCS does not provide extra benefit for CRF in supervised, well-controlled exercise interventions.en_US
dc.language.isoengen_US
dc.subjectbehavior changeen_US
dc.subjectcancer-related fatigueen_US
dc.subjectendurance trainingen_US
dc.subjectoncologyen_US
dc.subjectresistance trainingen_US
dc.titleDoes exercise intensity matter for fatigue during (neo-)adjuvant cancer treatment?: The phys-can randomized clinical trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2021 The Authorsen_US
dc.source.pagenumber1144-1159en_US
dc.source.volume31en_US
dc.source.journalScandinavian Journal of Medicine & Science in Sportsen_US
dc.source.issue5en_US
dc.identifier.doi10.1111/sms.13930
dc.identifier.cristin1916447
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


Files in this item

Thumbnail

This item appears in the following Collection(s)

Show simple item record