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dc.contributor.authorAas, Sigve Nyvik
dc.contributor.authorTømmerbakke, Daniel
dc.contributor.authorGodager, Sindre
dc.contributor.authorNordseth, Martin
dc.contributor.authorArmani, Andrea
dc.contributor.authorSandri, Marco
dc.contributor.authorBenestad, Haakon Breien
dc.contributor.authorRaastad, Truls
dc.date.accessioned2021-10-20T10:56:38Z
dc.date.available2021-10-20T10:56:38Z
dc.date.created2021-01-19T13:41:05Z
dc.date.issued2020
dc.identifier.citationExperimental Gerontology. 2020, 142, Artikkel 111122en_US
dc.identifier.issn0531-5565
dc.identifier.urihttps://hdl.handle.net/11250/2824097
dc.descriptionDette er siste tekst-versjon av artikkelen, og den kan inneholde små forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du her: http://dx.doi.org/10.1016/j.exger.2020.111122 / This is the final text version of the article, and it may contain minor differences from the journal's pdf version. The original publication is available here: http://dx.doi.org/10.1016/j.exger.2020.111122en_US
dc.description.abstractAging is associated with alterations in skeletal muscle autophagy, potentially affecting both muscle mass and quality in a negative manner. Strength training with protein supplementation has been reported to improve both muscle mass and quality in frail elderly individuals, but whether improvements are accompanied by alterations in protein quality control is not known. To address this issue, we investigated protein degradation markers in skeletal muscle biopsies (m. vastus lateralis) from twenty-four frail elderly men and women (86 ± 7 yr) after acute and chronic (10 weeks) strength training with protein supplementation (ST + PRO) or protein supplementation alone (PRO). Acute increases in mRNA expression of genes related to the ubiquitin proteasome system (MuRF-1, MUSA1), autophagy (ATG7, LC3, p62), and mitochondrial fission (DRP1) were observed after the first, but not after the last training session in ST + PRO. Acute changes in gene expression were accompanied by changes in protein levels of both LC3-I and LC3-II. Hence, the acute training-induced activation of proteasomal degradation and autophagy seems to depend on training status, with activation in the untrained, but not trained state. The ten-week training intervention did not affect basal levels of autophagy mRNAs and proteins, and neither markers of the ubiquitin-proteasome system. This suggests that a relatively short period of strength training may not be sufficient to increase the basal rate of protein degradation in frail elderly.en_US
dc.language.isoengen_US
dc.subjectresistance exerciseen_US
dc.subjectagingen_US
dc.subjectfrailtyen_US
dc.subjectanabolic resistanceen_US
dc.subjectprotein breakdownen_US
dc.titleEffects of acute and chronic strength training on skeletal muscle autophagy in frail elderly men and womenen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.pagenumber1-13en_US
dc.source.volume142:111122en_US
dc.source.journalExperimental Gerontologyen_US
dc.identifier.doi10.1016/j.exger.2020.111122
dc.identifier.cristin1874401
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.fulltextpostprint
cristin.qualitycode1


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