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dc.contributor.authorBarcellini, Amelia
dc.contributor.authorDominoni, Mattia
dc.contributor.authorMas, Francesca Dal
dc.contributor.authorBiancuzzi, Helena
dc.contributor.authorVenturini, Sara Carla
dc.contributor.authorGardella, Barbara
dc.contributor.authorOrlandi, Ester
dc.contributor.authorBø, Kari
dc.date.accessioned2022-03-22T21:44:30Z
dc.date.available2022-03-22T21:44:30Z
dc.date.created2022-02-03T11:08:31Z
dc.date.issued2022
dc.identifier.citationFrontiers in Medicine. 2022, 8, Artikkel 813352.en_US
dc.identifier.issn2296-858X
dc.identifier.urihttps://hdl.handle.net/11250/2986924
dc.descriptionThis is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.en_US
dc.description.abstractIntroduction: The present study aims to describe: 1. How the side effects of radiotherapy (RT) could impact sexual health in women; 2. The effectiveness of physical rehabilitation including pelvic floor muscle training (PFMT) in the management of sexual dysfunction after RT. Materials and Methods: Search keys on PubMed, Web of Science, Scopus, PEDro, and Cochrane were used to identify studies on women treated with radical or adjuvant RT and/or brachytherapy for gynecological cancers with an emphasis on vulvo-vaginal toxicities and PFMT studies on sexual dysfunction for this group of women. Results: Regarding the first key question, we analyzed 19 studies including a total of 2,739 women who reported vaginal dryness, stenosis, and pain as the most common side effects. Reports of dosimetric risk factors and dose-effect data for vaginal and vulvar post-RT toxicities are scant. Only five studies, including three randomized controlled trials (RCTs), were found to report the effect of PFMT alone or in combination with other treatments. The results showed some evidence for the effect of training modalities including PFMT, but to date, there is insufficient evidence from high-quality studies to draw any conclusion of a possible effect. Conclusions: Gynecological toxicities after RT are common, and their management is challenging. The few data available for a rehabilitative approach on post-actinic vulvo-vaginal side effects are encouraging. Large and well-designed RCTs with the long-term follow-up that investigate the effect of PFMT on vulvo-vaginal tissues and pelvic floor muscle function are needed to provide further guidance for clinical management.en_US
dc.language.isoengen_US
dc.subjectgynecological cancersen_US
dc.subjectpelvic floor muscle trainingen_US
dc.subjectradiotherapyen_US
dc.subjectrehabilitationen_US
dc.subjectsexual healthen_US
dc.subjectvaginal toxicityen_US
dc.titleSexual health dysfunction after radiotherapy for gynecological cancer: Role of physical rehabilitation including pelvic floor muscle trainingen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2022 Barcellini, Dominoni, Dal Mas, Biancuzzi, Venturini, Gardella, Orlandi and Bøen_US
dc.source.pagenumber13en_US
dc.source.volume8en_US
dc.source.journalFrontiers in Medicineen_US
dc.identifier.doi10.3389/fmed.2021.813352
dc.identifier.cristin1997319
dc.description.localcodeInstitutt for idrettsmedisinske fag / Department of Sports Medicineen_US
dc.source.articlenumber813352en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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