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dc.contributor.authorNilsen, Tormod Skogstad
dc.contributor.authorJohansen, Sara Hassing
dc.contributor.authorThorsen, Lene
dc.contributor.authorFairman, Ciaran M.
dc.contributor.authorWisløff, Torbjørn
dc.contributor.authorRaastad, Truls
dc.date.accessioned2022-08-04T09:14:36Z
dc.date.available2022-08-04T09:14:36Z
dc.date.created2022-04-10T13:56:42Z
dc.date.issued2022
dc.identifier.citationInternational Journal of Environmental Research and Public Health. 2022, 19(7), Artikkel 3820.en_US
dc.identifier.issn1661-7827
dc.identifier.urihttps://hdl.handle.net/11250/3010097
dc.descriptionThis is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
dc.description.abstractBackground: Loss of muscle mass and muscle function is a common side effect from androgen deprivation therapy (ADT) for prostate cancer (PCa). Here, we explored effects of heavy-load resistance training (RT) on lean body mass and muscle strength changes reported in randomized controlled trials (RCTs) among PCa patients on ADT and in healthy elderly men (HEM), by comparison of results in separate meta-analysis. Methods: RCTs were identified through databases and reference lists. Results: Seven RCTs in PCa patients (n = 449), and nine in HEM (n = 305) were included. The effects of RT in lean body mass change were similar among PCa patients (Standardized mean difference (SMD): 0.4, 95% CI: 0.2, 0.7) and HEM (SMD: 0.5, 95% CI: 0.2, 0.7). It is noteworthy that the within group changes showed different patterns in PCa patients (intervention: 0.2 kg; control: −0.6 kg) and HEM (intervention: 1.2 kg; control: 0.2 kg). The effects of RT on change in muscle strength (measured as 1 RM) were similar between PCa patients and HEM, both for lower body- (PCa: SMD: 1.9, 95% CI: 1.2, 2.5; HEM: SMD: 2.2, 95% CI: 1.0, 3.4), and for upper body exercises (PCa: SMD: 2.0, 95% CI: 1.3, 2.7; HEM: SMD: 1.9, 95% CI: 1.3, 2.6). Conclusions: The effects of RT on lean body mass and 1 RM were similar in PCa patients on ADT and HEM, but the mechanism for the intervention effect might differ between groups. It seems that RT counteracts loss of lean body mass during ADT in PCa patients, as opposed to increasing lean body mass in HEM.en_US
dc.language.isoengen_US
dc.subjectadaptationen_US
dc.subjectandrogen deprivation therapyen_US
dc.subjecthealthy elderly menen_US
dc.subjectprostate cancer patientsen_US
dc.subjectresistance exerciseen_US
dc.titleDoes androgen deprivation for prostate cancer affect normal adaptation to resistance exercise?en_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2022 by the authorsen_US
dc.source.pagenumber14en_US
dc.source.volume19en_US
dc.source.journalInternational Journal of Environmental Research and Public Healthen_US
dc.source.issue7en_US
dc.identifier.doi10.3390/ijerph19073820
dc.identifier.cristin2016473
dc.description.localcodeInstitutt for fysisk prestasjonsevne / Department of Physical Performanceen_US
dc.source.articlenumber3820en_US
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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