dc.contributor.author | Nilsen, Tormod Skogstad | |
dc.contributor.author | Johansen, Sara Hassing | |
dc.contributor.author | Thorsen, Lene | |
dc.contributor.author | Fairman, Ciaran M. | |
dc.contributor.author | Wisløff, Torbjørn | |
dc.contributor.author | Raastad, Truls | |
dc.date.accessioned | 2022-08-04T09:14:36Z | |
dc.date.available | 2022-08-04T09:14:36Z | |
dc.date.created | 2022-04-10T13:56:42Z | |
dc.date.issued | 2022 | |
dc.identifier.citation | International Journal of Environmental Research and Public Health. 2022, 19(7), Artikkel 3820. | en_US |
dc.identifier.issn | 1661-7827 | |
dc.identifier.uri | https://hdl.handle.net/11250/3010097 | |
dc.description | This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en_US |
dc.description.abstract | Background: Loss of muscle mass and muscle function is a common side effect from androgen deprivation therapy (ADT) for prostate cancer (PCa). Here, we explored effects of heavy-load resistance training (RT) on lean body mass and muscle strength changes reported in randomized controlled trials (RCTs) among PCa patients on ADT and in healthy elderly men (HEM), by comparison of results in separate meta-analysis.
Methods: RCTs were identified through databases and reference lists.
Results: Seven RCTs in PCa patients (n = 449), and nine in HEM (n = 305) were included. The effects of RT in lean body mass change were similar among PCa patients (Standardized mean difference (SMD): 0.4, 95% CI: 0.2, 0.7) and HEM (SMD: 0.5, 95% CI: 0.2, 0.7). It is noteworthy that the within group changes showed different patterns in PCa patients (intervention: 0.2 kg; control: −0.6 kg) and HEM (intervention: 1.2 kg; control: 0.2 kg). The effects of RT on change in muscle strength (measured as 1 RM) were similar between PCa patients and HEM, both for lower body- (PCa: SMD: 1.9, 95% CI: 1.2, 2.5; HEM: SMD: 2.2, 95% CI: 1.0, 3.4), and for upper body exercises (PCa: SMD: 2.0, 95% CI: 1.3, 2.7; HEM: SMD: 1.9, 95% CI: 1.3, 2.6).
Conclusions: The effects of RT on lean body mass and 1 RM were similar in PCa patients on ADT and HEM, but the mechanism for the intervention effect might differ between groups. It seems that RT counteracts loss of lean body mass during ADT in PCa patients, as opposed to increasing lean body mass in HEM. | en_US |
dc.language.iso | eng | en_US |
dc.subject | adaptation | en_US |
dc.subject | androgen deprivation therapy | en_US |
dc.subject | healthy elderly men | en_US |
dc.subject | prostate cancer patients | en_US |
dc.subject | resistance exercise | en_US |
dc.title | Does androgen deprivation for prostate cancer affect normal adaptation to resistance exercise? | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2022 by the authors | en_US |
dc.source.pagenumber | 14 | en_US |
dc.source.volume | 19 | en_US |
dc.source.journal | International Journal of Environmental Research and Public Health | en_US |
dc.source.issue | 7 | en_US |
dc.identifier.doi | 10.3390/ijerph19073820 | |
dc.identifier.cristin | 2016473 | |
dc.description.localcode | Institutt for fysisk prestasjonsevne / Department of Physical Performance | en_US |
dc.source.articlenumber | 3820 | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |