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dc.contributor.authorDePhillipo, Nicholas
dc.contributor.authorAman, Zachary S.
dc.contributor.authorDekker, Travis J.
dc.contributor.authorMoatshe, Gilbert
dc.contributor.authorChahla, Jorge
dc.contributor.authorLaPrade, Robert F.
dc.date.accessioned2022-09-15T09:33:40Z
dc.date.available2022-09-15T09:33:40Z
dc.date.created2021-12-09T11:00:17Z
dc.date.issued2021
dc.identifier.citationArthroscopy: The Journal of Arthroscopy And Related. 2021, 37(8), 2627-2639.en_US
dc.identifier.issn0749-8063
dc.identifier.urihttps://hdl.handle.net/11250/3017977
dc.descriptionI Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på sciencedirect.com / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The definitive version is available at sciencedirect.com.en_US
dc.description.abstractPurpose: To conduct a review of active United States–based clinical trials investigating preventative, symptom resolution, and disease-modifying therapies for osteoarthritis (OA). Methods: We conducted a review of currently active clinical trials for OA using data obtained from the ClinicalTrials.gov database as of August 2020. The inclusion criteria were active studies registered in the United States that involved the prevention, symptom resolution, or disease modification of OA. Descriptive statistics were recorded and summarized. Results: A total of 3,859 clinical trials were identified, and 310 were included in the final analysis. Of the currently active trials, 89% (n = 275) targeted symptom resolution in patients with existing OA, 6% (n = 19) targeted OA disease-modifying therapeutics, and 5% (n = 16) targeted the prevention of OA in high-risk patients (P < .001). Primary interventions included medical devices (44%, n = 137), pharmaceutical drugs (14%, n = 42), surgical procedures (14%, n = 42), cellular biologics (13%, n = 41), and behavioral therapies (13%, n = 41). There was a significantly higher number of disease-modifying therapeutics for cellular biologics than pharmaceutical drugs (30% vs 14%) (P = .015). Most trials targeted the knee joint (63%, P = .042), with 38% of all trials evaluating joint arthroplasty. There were no significant differences between private sector and government funding sources (43% and 49%, respectively) (P = .288), yet there was a significantly lower rate of funding from industry (8%) (P = .026). Conclusions: There was a significantly higher number of clinical trials investigating symptomatic resolution therapy (89%) for existing OA in comparison to preventative (5%) and disease-modifying (6%) therapies. The most common interventions involved medical devices and joint replacement surgery, with the knee joint accounting for more than 60% of the current clinical trials for OA. There was a significantly higher number of disease-modifying therapeutics for cellular biologics than pharmaceutical drugs. Funding of clinical trials was split between the private sector and government, with a low rate of reported funding from industry partners.en_US
dc.language.isoengen_US
dc.subjecthumansen_US
dc.subjectknee jointen_US
dc.subjectosteoarthritis, kneeen_US
dc.titlePreventative and Disease-Modifying Investigations for Osteoarthritis Management Are Significantly Under-represented in the Clinical Trial Pipeline: A 2020 Reviewen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionacceptedVersionen_US
dc.source.pagenumber2627-2639en_US
dc.source.volume37en_US
dc.source.journalArthroscopy: The Journal of Arthroscopy And Relateden_US
dc.source.issue8en_US
dc.identifier.doi10.1016/j.arthro.2021.03.050
dc.identifier.cristin1966574
dc.description.localcodeInstitutt for idrettsmedisinske fag / Department of Sports Medicineen_US
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


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