Vis enkel innførsel

dc.contributor.authorAhmadi, Matthew N.
dc.contributor.authorBlodgett, Joanna M.
dc.contributor.authorAtkin, Andrew J
dc.contributor.authorChan, Hsiu-Wen
dc.contributor.authordel Pozo Cruz, Borja
dc.contributor.authorSuorsa, Kristin
dc.contributor.authorBakker, Esmée A.
dc.contributor.authorPulsford, Richard M.
dc.contributor.authorMielke, Gregore I
dc.contributor.authorJohansson, Peter
dc.contributor.authorHettiarachchi, Pasan
dc.contributor.authorThijssen, Dick H.J.
dc.contributor.authorStenholm, Sari
dc.contributor.authorMishra, Gita D
dc.contributor.authorTeixeira-Pinto, Armando
dc.contributor.authorRangul, Vegar
dc.contributor.authorSherar, Lauren B
dc.contributor.authorEkelund, Ulf
dc.contributor.authorHughes, Alun D
dc.contributor.authorLee, I-Min
dc.contributor.authorHoltermann, Andreas
dc.contributor.authorKoster, Annemarie
dc.contributor.authorHamer, Mark
dc.contributor.authorStamatakis, Emmanuel
dc.date.accessioned2024-11-01T15:55:14Z
dc.date.available2024-11-01T15:55:14Z
dc.date.created2024-03-18T13:10:15Z
dc.date.issued2024
dc.identifier.citationDiabetologia. 2024, 67(6), Side 1051-1065.en_US
dc.identifier.issn0012-186X
dc.identifier.urihttps://hdl.handle.net/11250/3162167
dc.description.abstractAims/hypothesis: The aim of this study was to examine the dose–response associations of device-measured physical activity types and postures (sitting and standing time) with cardiometabolic health. Methods: We conducted an individual participant harmonised meta-analysis of 12,095 adults (mean ± SD age 54.5±9.6 years; female participants 54.8%) from six cohorts with thigh-worn accelerometry data from the Prospective Physical Activity, Sitting and Sleep (ProPASS) Consortium. Associations of daily walking, stair climbing, running, standing and sitting time with a composite cardiometabolic health score (based on standardised z scores) and individual cardiometabolic markers (BMI, waist circumference, triglycerides, HDL-cholesterol, HbA1c and total cholesterol) were examined cross-sectionally using generalised linear modelling and cubic splines. Results: We observed more favourable composite cardiometabolic health (i.e. z score [95% CI] −0.14 [−0.25, −0.02]) and 5 min/day stair climbing (−0.14 [−0.24, −0.03]). We observed an equivalent magnitude of association at 2.6 h/day standing. Any amount of running was associated with better composite cardiometabolic health. We did not observe an upper limit to the magnitude of the dose–response associations for any activity type or standing. There was an inverse dose–response association between sitting time and composite cardiometabolic health that became markedly less favourable when daily durations exceeded 12.1 h/day. Associations for sitting time were no longer significant after excluding participants with prevalent CVD or medication use. The dose–response pattern was generally consistent between activity and posture types and individual cardiometabolic health markers. Conclusions/interpretation: In this first activity type-specific analysis of device-based physical activity, ~64 min/day of walking and ~5.0 min/day of stair climbing were associated with a favourable cardiometabolic risk profile. The deleterious associations of sitting time were fully attenuated after exclusion of participants with prevalent CVD and medication use. Our findings on cardiometabolic health and durations of different activities of daily living and posture may guide future interventions involving lifestyle modification.en_US
dc.language.isoengen_US
dc.rightsNavngivelse 4.0 Internasjonal*
dc.rights.urihttp://creativecommons.org/licenses/by/4.0/deed.no*
dc.subjectcardiometabolic healthen_US
dc.subjectindividual participant meta-analysisen_US
dc.subjectphysical activity typeen_US
dc.subjectpostureen_US
dc.subjectrunningen_US
dc.subjectsittingen_US
dc.subjectstair climbingen_US
dc.subjectstandingen_US
dc.subjectwalkingen_US
dc.subjectwearablesen_US
dc.titleRelationship of device measured physical activity type and posture with cardiometabolic health markers: Pooled dose–response associations from the Prospective Physical Activity, Sitting and Sleep Consortiumen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.source.pagenumber1051-1065en_US
dc.source.volume67en_US
dc.source.journalDiabetologiaen_US
dc.source.issue6en_US
dc.identifier.doi10.1007/s00125-024-06090-y
dc.identifier.cristin2255391
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode2


Tilhørende fil(er)

Thumbnail
Thumbnail

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel

Navngivelse 4.0 Internasjonal
Med mindre annet er angitt, så er denne innførselen lisensiert som Navngivelse 4.0 Internasjonal