Browsing Brage NIH by Author "Landen, Shanie"
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Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle
Voisin, Sarah; Seale, Kirsten; Jacques, Macsue; Landen, Shanie; Coffey, Vernon G.; Walsh, Colum; Davison, Gareth; McBride, Catherine; Irwin, Rachelle; Hansson, Ola; Asplund, Olof; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Ashton, Kevin J.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Lindholm, Maléne E.; Sharples, Adam P.; Eynon, Nir (Peer reviewed; Journal article, 2023)Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training ... -
Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle
Voisin, Sarah; Jacques, Macsue; Landen, Shanie; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Gancheva, Sofiya; Ouni, Meriem; Jähnert, Marcus; Ashton, Kevin J.; Coffey, Vernon G.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Gabory, Anne; Junien, Claudine; Caiazzo, Robert; Verkindt, Hélène; Raverdy, Violetta; Pattou, Francois; Froguel, Philippe; Blocquiaux, Sara; Thomis, Martine; Roden, Michael; Horvath, Steve; Eynon, Nir; Craig, Jeffrey M.; Sharples, Adam P.; Schürmann, Annette (Peer reviewed; Journal article, 2021)Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ...