Browsing Brage NIH by Author "Jensen, Jørgen"
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A combined and intensive exercise model improves physical capacity in cardiac patients
Sveen, Ole; Skaug, Arne; Hanssen, Knut Egil; Jensen, Jørgen; Christoffersen, Trine Eker (Peer reviewed; Journal article, 2017)Objective: We have measured the effect of combined strength and high intensity endurance training on physical capacity and lipid profile in patients with heart and coronary diseases. We wanted to see whether cardiac patients ... -
An acute bout of endurance exercise does not prevent the inhibitory effect of caffeine on glucose tolerance the following morning
Fenne, Karoline Tusvik; Clauss, Matthieu; Olstad, Daniela Schäfer; Johansen, Egil Ivar; Jensen, Jørgen (Peer reviewed; Journal article, 2023)Caffeine reduces glucose tolerance, whereas exercise training improves glucose homeostasis. The aim of the present study was to investigate the effect of caffeine on glucose tolerance the morning after an acute bout of ... -
Aged cells in human skeletal muscle after resistance exercise
Yang, Chi; Jiao, Ying; Wei, Bing; Yang, Zeyi; Wu, Jin-Fu; Jensen, Jørgen; Jean, Wei-Horng; Huang, Chih-Yang; Kuo, Chia-Hua (Journal article; Peer reviewed, 2018)It remains unclear how exercise, as an entropic event, brings benefit against human aging. Here we examined longitudinal changes of p16Ink4a+ senescent cells in skeletal muscle of young men (aged 22.5±1.7 y) before and ... -
Beta-Adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA
Stuenæs, Jorid T.; Bolling, Astrid; Ingvaldsen, Ada; Rommundstad, Camilla; Sudar, Emina; Lin, Fang-Chin; Lai, Yu-Chiang; Jensen, Jørgen (Journal article; Peer reviewed, 2010-03-23)BACKGROUND AND PURPOSE: Genetic approaches have documented protein kinase B (PKB) as a pivotal regulator of heart function. Insulin strongly activates PKB, whereas adrenaline is not considered a major physiological regulator ... -
Branched-chain amino acid metabolism, insulin sensitivity and liver fat response to exercise training in sedentary dysglycaemic and normoglycaemic men
Lee, Sindre; Gulseth, Hanne Løvdal; Langleite, Torgrim Mikal; Norheim, Frode; Olsen, Thomas; Refsum, Helga; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A (Peer reviewed; Journal article, 2020)Aims/hypothesis: Obesity and insulin resistance may be associated with elevated plasma concentration of branched-chain amino acids (BCAAs) and impaired BCAA metabolism. However, it is unknown whether the insulin-sensitising ... -
Branched-chain amino acids supplementation does not accelerate recovery after a change of direction sprinting exercise protocol
Khemtong, Chutimon; Tessitore, Antonio; Jaime, Salvador J.; Gobbi, Giuliana; Jensen, Jørgen; Yang, Ai-Lun; Kuo, Chia-Hua; Condello, Giancarlo (Peer reviewed; Journal article, 2022)BCAAs supplementation has been widely used for post-exercise recovery. However, no evidence is currently available to answer the question of whether BCAAs supplementation can attenuate muscle damage and ameliorate recovery ... -
Caffeine and performance over consecutive days of simulated competition
Stadheim, Hans Kristian; Spencer, Matt; Olsen, Raymond; Jensen, Jørgen (Journal article; Peer reviewed, 2015-09)Purpose: Performance improvements after caffeine (CAF) ingestion are well documented when using a 1-d protocol. In numerous competitions such as the Tour de France, Tour de Ski, world championships, and National College ... -
Caffeine increases performance in cross-country double-poling time trial exercise
Stadheim, Hans Kristian; Kvamme, Bent; Olsen, Raymond; Ivy, John L.; Drevon, Christian A.; Ivy, John L.; Jensen, Jørgen (Journal article; Peer reviewed, 2013-11)PURPOSE: Caffeine (CAF) improves performance in both short- and long-duration running and cycling where performance relies on power output and endurance capacity of leg muscles. No studies have so far tested ... -
Cardiorespiratory fitness assessment using risk-stratified exercise testing and dose–response relationships with disease outcomes
Gonzales, Tomas I.; Westgate, Kate; Strain, Tessa; Hollidge, Stefanie; Jeon, Justin; Christensen, Dirk L.; Jensen, Jørgen; Wareham, Nicholas J.; Brage, Søren (Peer reviewed; Journal article, 2021)Cardiorespiratory fitness (CRF) is associated with mortality and cardiovascular disease, but assessing CRF in the population is challenging. Here we develop and validate a novel framework to estimate CRF (as maximal oxygen ... -
Circulating small non-coding RNAs as biomarkers for recovery after exhaustive or repetitive exercise
Håkansson, Kjell EJ; Sollie, Ove; Simons, Karin H; Quax, Paul H.A.; Jensen, Jørgen; Nossent, AYael (Journal article; Peer reviewed, 2018)Circulating microRNAs have proven to be reliable biomarkers, due to their high stability, both in vivo in the circulation, and ex vivo during sample preparation and storage. Small nucleolar RNAs (snoRNAs) are a different ... -
Coingestion of protein and carbohydrate in the early recovery phase, compared with carbohydrate only, improves endurance performance despite similar glycogen degradation and AMPK phosphorylation
Dahl, Marius; Areta, José; Jeppesen, Per Bendix; Birk, Jesper B.; Johansen, Egil Ivar; Ingemann-Hansen, Thorsten; Mette, Hansen; Skålhegg, Bjørn Steen; Ivy, John L.; Wojtaszewski, Jorgen; Kristian, Overgaard; Jensen, Jørgen (Peer reviewed; Journal article, 2020)The present study compared the effects of postexercise carbohydrate plus protein (CHO+PROT) and carbohydrate (CHO)-only supplementation on muscle glycogen metabolism, anabolic cell signaling, and subsequent exercise ... -
Combined intervention with pioglitazone and n-3 fatty acids in metformin-treated type 2 diabetic patients: improvement of lipid metabolism.
Veleba, Jiri; Kopecký, Jan; Janovská, Petra; Kuda, Ondrej; Horakova, Olga; Malinská, Hana; Kazdova, Ludmila; Oliyarnyk, Olena; Škop, Vojtěch; Trnovská, Jaroslava; Hájek, Milan; Škoch, Antonín; Flachs, Pavel; Bardová, Kristina; Rossmeisl, Martin; Olza, Josune; De Castro, Gabriela Salim; Calder, Philip C.; Gardlo, Alžběta; Fišerová, Eva; Jensen, Jørgen; Bryhn, Morten; Kopecky, Jan; Pelikánová, Terezie (Journal article; Peer reviewed, 2015-12-02)Methods: In a parallel-group, four-arm, randomized trial, 69 patients (66 % men) were assigned to 24-week-intervention using: (i) corn oil (5 g/day; Placebo), (ii) pioglitazone (15 mg/day; Pio), (iii) EPA + DHA concentrate ... -
Decreased insulin-stimulated brown adipose tissue glucose uptake after short-term exercise training in healthy middle-aged men
Motiani, Piryanka; Virtanen, Kirsi; Motiani, Kumail K; Eskelinen, Joonas J; Middelbeek, Roeland J; Goodyear, Laurie J.; Savolainen, Anna M; Kemppainen, Jukka; Jensen, Jørgen; Din, Mueez U; Saunavaara, Virva; Parkkola, Riitta; Loyttyniemi, Eliisa; Knuuti, Juhani; Nuutila, Pirjo; Kalliokoski, Kari K.; Hannukainen, Jarna C (Journal article; Peer reviewed, 2017)Aims: To test the hypothesis that high‐intensity interval training (HIIT) and moderate‐intensity continuous training (MICT) improve brown adipose tissue (BAT) insulin sensitivity. Participants and methods: Healthy ... -
Differential effects of one meal per day in the evening on metabolic health and physical performance in lean individuals
Meessen, Emma C. E.; Andresen, Håvard; van Barneveld, Thomas; van Riel, Anne; Johansen, Egil Ivar; Kolnes, Anders Jensen; Kemper, E. Marleen; Schaap, Frank G.; Romijn, Johannes A.; Jensen, Jørgen; Soeters, Maarten R.; Damink, Steven W. M. Olde (Peer reviewed; Journal article, 2022)Background: Generally, food intake occurs in a three-meal per 24 h fashion with in-between meal snacking. As such, most humans spend more than ∼ 12–16 h per day in the postprandial state. It may be reasoned from an ... -
Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise
Pourteymour, Shirin; Hjorth, Marit; Lee-Ødegård, Sindre; Holen, Torgeir; Langleite, Torgrim Mikal; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A; Eckardt, Kristin (Journal article; Peer reviewed, 2017)Physical activity promotes specific adaptations in most tissues including skeletal muscle. Acute exercise activates numerous signaling cascades including pathways involving mitogen‐activated protein kinases (MAPKs) such ... -
Effect of a Low-Carbohydrate High-Fat Diet and a Single Bout of Exercise on Glucose Tolerance, Lipid Profile and Endothelial Function in Normal Weight Young Healthy Females
Valsdottir, Thorhildur; Henriksen, Christine; Odden, Nancy; Nellemann, Birgitte; Jeppesen, Per Bendix; Hisdal, Jonny; Westerberg, Ane Cecilie; Jensen, Jørgen (Peer reviewed; Journal article, 2019)Low-carbohydrate-high-fat (LCHF) diets are efficient for weight loss, and are also used by healthy people to maintain bodyweight. The main aim of this study was to investigate the effect of 3-week energy-balanced LCHF-diet, ... -
Effect of aerobic exercise and low-carbohydrate high-fat diet on glucose tolerance and android/gynoid fat in overweight/obese women: A randomized controlled trial
Valsdottir, Thorhildur Ditta; Øvrebø, Bente; Kornfeldt, Thea Martine; Litleskare, Sigbjørn; Johansen, Egil Ivar; Henriksen, Christine; Jensen, Jørgen (Peer reviewed; Journal article, 2023)The study was designed to compare the effects of weight loss induced by a low-carbohydrate-high-fat diet or a normal diet, with and without exercise, on glucose tolerance measured as area under the curve (AUC), and android ... -
Effect of energy restriction and physical exercise intervention on phenotypic flexibility as examined by transcriptomics analyses of mRNA from adipose tissue and whole body magnetic resonance imaging
Lee, Sindre; Norheim, Frode; Langleite, Torgrim M.; Noreng, Hans J.; Storås, Trygve H.; Afman, Lydia A.; Frost, Gary; Bell, Jimmy D.; Thomas, E. Louise; Kolnes, Kristoffer J.; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor D.; Gulseth, Hanne L.; Birkeland, Kåre I.; Jensen, Jørgen; Drevon, Christian A.; Holen, Torgeir (Journal article; Peer reviewed, 2016-11-07)Overweight and obesity lead to changes in adipose tissue such as inflammation and reduced insulin sensitivity. The aim of this study was to assess how altered energy balance by reduced food intake or enhanced physical ... -
Effect of exercise training on fat loss—Energetic perspectives and the role of improved adipose tissue function and body fat distribution
Kolnes, Kristoffer Jensen; Petersen, Maria Houborg; Lien-Iversen, Teodor; Højlund, Kurt; Jensen, Jørgen (Peer reviewed; Journal article, 2021)In obesity, excessive abdominal fat, especially the accumulation of visceral adipose tissue (VAT), increases the risk of metabolic disorders, such as type 2 diabetes mellitus (T2DM), cardiovascular disease, and non-alcoholic ... -
Effects of carbohydrate and protein supplement strategies on endurance capacity and muscle damage of endurance runners: A double blind, controlled crossover trial
Liang, Yiheng; Chen, Yan; Yang, Fan; Jensen, Jørgen; Gao, Ruirui; Yi, Longyan; Qiu, Junqiang (Peer reviewed; Journal article, 2022)Background: The purpose of this study is to explore the effect of carbohydrate only or carbohydrate plus protein supplementation on endurance capacity and muscle damage. Methods: Ten recreationally active male runners ...