Browsing Norges idrettshøgskole by Subject "ageing"

Now showing items 1-9 of 9

    • DNA methylation across the genome in aged human skeletal muscle tissue and muscle‑derived cells: The role of HOX genes and physical activity 

      Turner, Daniel C.; Gorski, Piotr Patryk; Massar, Mohd Firdaus; Seaborne, Robert A.; Baumert, Phillipp; Brown, Alexander D.; Erskine, Robert M.; Dos-Remedios, Ian; Voisin, Sarah; Eynon, Nir; Borisov, Oleg; Larin, Andrey; Semenova, Ekaterina A.; Popov, Daniil; Drust, Barry; Owens, Daniel J.; Ahmetov, Ildus I.; Sharples, Adam; Kitchen, Mark O.; Sultanov, R. I.; Generozov, Edward V.; Stewart, Claire E. (Peer reviewed; Journal article, 2020)
      Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue ...

    • Effect of 5 years of exercise training on the cardiovascular risk profile of older adults: The Generation 100 randomized trial 

      Letnes, Jon Magne; Berglund, Ida Johnsen; Johnson, Kristin Espolin; Dalen, Håvard; Lydersen, Stian; Viken, Hallgeir; Hassel, Erlend; Steinshamn, Sigurd Loe; Vesterbekkmo, Elisabeth Kleivhaug; Støylen, Asbjørn; Reitlo, Line Skarsem; Zisko, Nina; Bækkerud, Fredrik Hjulstad; Tari, Atefe R; Ingebrigtsen, Jan Erik; Carlsen, Trude; Anderssen, Sigmund Alfred; Singh, Maria A. Fiatarone; Coombes, Jeff S.; Helbostad, Jorunn L.; Rognmo, Øivind; Wisløff, Ulrik; Stensvold, Dorthe; Nes, Bjarne M.; Sandbakk, Silvana Bucher (Peer reviewed; Journal article, 2021)
      Aims The aim of this study was to compare the effects of 5 years of supervised exercise training (ExComb), and the differential effects of subgroups of high-intensity interval training (HIIT) and moderate-intensity ...

    • An epigenetic clock for human skeletal muscle 

      Voisin, Sarah; Harvey, Nicholas R; Haupt, Larisa M; Griffiths, Lyn R; Aston, Kevin J; Coffey, Vernon G.; Doering, Thomas M; Thompson, Jamie-Lee M; Benedict, Christian; Cedernaes, Jonathan; Lindholm, Malene E; Craig, Jeffrey M; Rowlands, David S; Sharples, Adam; Horvath, Steve; Eynon, Nir (Peer reviewed; Journal article, 2020)
      Background: Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the ...

    • Evaluation of reliability and validity of the General Practice Physical Activity Questionnaire (GPPAQ) in 60–74 year old primary care patients 

      Ahmad, Shaleen; Harris, Tess; Limb, Elizabeth S.; Kerry, Sally; Victor, Christina; Ekelund, Ulf; Iliffe, Steve; Whincup, Peter; Beighton, Carole; Ussher, Michael; Cook, Derek G. (Journal article; Peer reviewed, 2015-09-02)
      BACKGROUND: GPPAQ (General Practice Physical Activity Questionnaire) is a self-assessment physical activity questionnaire widely used in primary care. Reliability and validity data in older people are lacking. The ...

    • ‘It is passable, I suppose’: adult Norwegian men’s notions of their own bodies 

      Hervik, Stein Egil; Fasting, Kari (Journal article; Peer reviewed, 2014-11-07)
      The aim of this paper is to contribute to a better understanding of how men aged 40–90 years with different educational and ethnic backgrounds talk about their own bodies, and how social dimensions, especially masculinity ...

    • Maximal aerobic power and anaerobic capacity in cycling across the age spectrum in male master athletes 

      Capelli, Carlo; Rittveger, J.; Bruseghini, Paolo; Calabria, E.; Tam, Enrico (Journal article; Peer reviewed, 2016-05)
      Purpose: We analyzed the best performance times of master cycling athletes in the 200–3000 m track competitions to estimate the decay of maximal aerobic power (MAP) and anaerobic capacity (AnS) with aging. Methods: In ...

    • Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle 

      Voisin, Sarah; Jacques, Macsue; Landen, Shanie; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Gancheva, Sofiya; Ouni, Meriem; Jähnert, Marcus; Ashton, Kevin J.; Coffey, Vernon G.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Gabory, Anne; Junien, Claudine; Caiazzo, Robert; Verkindt, Hélène; Raverdy, Violetta; Pattou, Francois; Froguel, Philippe; Blocquiaux, Sara; Thomis, Martine; Roden, Michael; Horvath, Steve; Eynon, Nir; Craig, Jeffrey M.; Sharples, Adam P.; Schürmann, Annette (Peer reviewed; Journal article, 2021)
      Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ...

    • Physiological and functional evaluation of healthy young and older men and women: design of the European MyoAge study 

      McPhee, Jamie S.; Hogrel, Jean-Yves; Maier, Andrea B.; Seppet, Enn; Seynnes, Olivier R.; Sipilä, Sarianna; Bottinelli, Roberto; Barnouin, Yoann; Bijlsma, Astrid Y.; Gapeyeva, Helena; Maden-Wilkinson, Thomas M.; Meskers, Carel G.; Pääsuke, Mati; Sillanpää, Elina; Sentroth, Lauri; Butler-Browne, Gillian; Narici, Marco V.; Jones, David A. (Journal article; Peer reviewed, 2013-05-31)
      Within the European multi-centre MyoAge project, one workpackage was designed to investigate the contribution of age-related changes to muscle mass, contractile characteristics and neural control in relation to reductions ...

    • Survival in elderly men in relation to midlife and current BMI 

      Holme, Ingar Morten K.; Tonstad, Serena (Journal article; Peer reviewed, 2015-01-21)
      Background: the relationship between BMI and mortality is U-shaped in the elderly but may be modified by midlife BMI and change in weight. Objective: to elucidate mortality prediction by BMI trajectory in older ...