Browsing Norges idrettshøgskole by Subject "epigenetics"

Now showing items 1-4 of 4

    • DNA methylation across the genome in aged human skeletal muscle tissue and muscle‑derived cells: The role of HOX genes and physical activity 

      Turner, Daniel C.; Gorski, Piotr Patryk; Massar, Mohd Firdaus; Seaborne, Robert A.; Baumert, Phillipp; Brown, Alexander D.; Erskine, Robert M.; Dos-Remedios, Ian; Voisin, Sarah; Eynon, Nir; Borisov, Oleg; Larin, Andrey; Semenova, Ekaterina A.; Popov, Daniil; Drust, Barry; Owens, Daniel J.; Ahmetov, Ildus I.; Sharples, Adam; Kitchen, Mark O.; Sultanov, R. I.; Generozov, Edward V.; Stewart, Claire E. (Peer reviewed; Journal article, 2020)
      Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue ...

    • Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle 

      Voisin, Sarah; Jacques, Macsue; Landen, Shanie; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Gancheva, Sofiya; Ouni, Meriem; Jähnert, Marcus; Ashton, Kevin J.; Coffey, Vernon G.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Gabory, Anne; Junien, Claudine; Caiazzo, Robert; Verkindt, Hélène; Raverdy, Violetta; Pattou, Francois; Froguel, Philippe; Blocquiaux, Sara; Thomis, Martine; Roden, Michael; Horvath, Steve; Eynon, Nir; Craig, Jeffrey M.; Sharples, Adam P.; Schürmann, Annette (Peer reviewed; Journal article, 2021)
      Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ...

    • Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle 

      Ruple, Bradley A; Godwin, Joshua S.; Mesquita, Paulo H. C; Osburn, Shelby C; Vann, Christopher G; Lamb, Donald A; Sexton, Casey L; Candow, Darren G; Forbes, Scott C; Frugé, Andrew D.; Kavazis, Andreas N; Young, Kaelin C; Seaborne, Robert A.; Sharples, Adam; Roberts, Michael D (Peer reviewed; Journal article, 2021)
      Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males (65 ...

    • Skeletal Muscle Memory 

      Sharples, Adam; Turner, Daniel (Peer reviewed; Journal article, 2023)
      Skeletal muscle memory is an exciting phenomenon gaining significant traction across several scientific communities, amongst exercise practitioners and the public. Research has demonstrated that skeletal muscle tissue can ...