Browsing Norges idrettshøgskole by Subject "skeletal muscle"
Now showing items 1-20 of 25
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Acute and long-term effects of blood flow restricted training on heat shock proteins and endogenous antioxidant systems
(Journal article; Peer reviewed, 2016)Blood flow restricted exercise (BFRE) with low loads has been demonstrated to induce considerable stress to exercising muscles. Muscle cells have developed a series of defensive systems against exercise-induced stress. ... -
Aging, Skeletal Muscle, and Epigenetics
(Peer reviewed; Journal article, 2022)We are living in an aging society. In 2019, 1 billion individuals were already aged over 60. The number of people in this demographic is predicted to reach 1.4 billion by 2030 and 2.1 billion by 2050 (WHO). In the USA, ... -
Chronic obstructive pulmonary disease does not impair responses to resistance training
(Peer reviewed; Journal article, 2021)Background: Subjects with chronic obstructive pulmonary disease (COPD) are prone to accelerated decay of muscle strength and mass with advancing age. This is believed to be driven by disease-inherent systemic pathophysiologies, ... -
Dual specificity phosphatase 5 and 6 are oppositely regulated in human skeletal muscle by acute exercise
(Journal article; Peer reviewed, 2017)Physical activity promotes specific adaptations in most tissues including skeletal muscle. Acute exercise activates numerous signaling cascades including pathways involving mitogen‐activated protein kinases (MAPKs) such ... -
An epigenetic clock for human skeletal muscle
(Peer reviewed; Journal article, 2020)Background: Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the ... -
Exercise mitigates the loss of muscle mass by attenuating the activation of autophagy during severe energy deficit
(Peer reviewed; Journal article, 2019)The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise ... -
Functional and Structural Adaptations of Skeletal Muscle in Long-Term Juvenile Dermatomyositis: a Controlled Cross-Sectional Study
(Peer reviewed; Journal article, 2019)Objective: To compare muscle strength and endurance of the knee extensors between patients with long‐term juvenile dermatomyositis (DM) and controls and between patients with active disease and those with inactive disease, ... -
Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise
(Journal article; Peer reviewed, 2017-03-03)Background: High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expression ... -
Impact of resistance exercise on ribosome biogenesis is acutely regulated by post‐exercise recovery strategies
(Journal article; Peer reviewed, 2016-01-26)Muscle hypertrophy occurs following increased protein synthesis, which requires activation of the ribosomal complex. Additionally, increased translational capacity via elevated ribosomal RNA (rRNA) synthesis has also been ... -
Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women
(Journal article; Peer reviewed, 2014-06-07)Purpose: To investigate the effects of strength training on abundances of irisin-related biomarkers in skeletal muscle and blood of untrained young women, and their associations with body mass composition, muscle phenotype ... -
Knockdown of the E3 Ubiquitin ligase UBR5 and its role in skeletal muscle anabolism
(Peer reviewed; Journal article, 2020)UBR5 is an E3-ubiquitin-ligase positively associated with anabolism, hypertrophy and recovery from atrophy in skeletal muscle. The precise mechanisms underpinning UBR5's role in the regulation of skeletal muscle mass remains ... -
Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo
(Peer reviewed; Journal article, 2021)Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of ... -
Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle
(Peer reviewed; Journal article, 2021)Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ... -
MicroRNAs in muscle: characterizing the powerlifter phenotype
(Journal article; Peer reviewed, 2017-06-07)Powerlifters are the epitome of muscular adaptation and are able to generate extreme forces. The molecular mechanisms underpinning the significant capacity for force generation and hypertrophy are not fully elucidated. ... -
Mimicking exercise in vitro - effects of myotube contractions and mechanical stretch on omics
(Peer reviewed; Journal article, 2023)The number of studies using skeletal muscle (SkM) cell culture models to study exercise in vitro are rapidly expanding. Progressively, more comprehensive analysis methods, such as different omics approaches including ... -
Muscular HSP70 content is higher in elderly compared to young, but is normalized after 12 weeks of strength training
(Peer reviewed; Journal article, 2021)Purpose: Aging is associated with increased myocellular stress and loss of muscle mass and function. Heat shock proteins (HSPs) are upregulated during periods of stress as part of the cells protective system. Exercise can ... -
Native whey induces similar post exercise muscle anabolic responses as regular whey, despite greater leucinemia, in elderly individuals
(Journal article; Peer reviewed, 2018)Objective: Elderly muscle seems less sensitive to the anabolic stimulus of a meal. Changes in blood concentrations of leucine are suggested as one important trigger of the anabolic response in muscle. The aim of this study ... -
Native whey protein with high levels of leucine results in similar post-exercise muscular anabolic responses as regular whey protein: A randomized controlled trial
(Academic article, 2017-11-21)Protein ingestion produces a strong anabolic stimulus that elevates muscle protein synthesis [34]. The ability of a serving of protein to stimulate muscle protein synthesis (MPS) is dependent on absorption and blood kinetics ... -
Peripheral adaptations to endurance training - Effect of active muscle mass
(Peer reviewed; Journal article, 2019)The purpose of this study was to evaluate whether adaptations to endurance training are affected by active muscle mass during training. Eleven healthy subjects performed 5 weeks of one‐legged knee extension (1‐KE) training ... -
Physiological and functional evaluation of healthy young and older men and women: design of the European MyoAge study
(Journal article; Peer reviewed, 2013-05-31)Within the European multi-centre MyoAge project, one workpackage was designed to investigate the contribution of age-related changes to muscle mass, contractile characteristics and neural control in relation to reductions ...