• Aging, Skeletal Muscle, and Epigenetics 

      Stewart, Claire E.; Sharples, Adam (Peer reviewed; Journal article, 2022)
      We are living in an aging society. In 2019, 1 billion individuals were already aged over 60. The number of people in this demographic is predicted to reach 1.4 billion by 2030 and 2.1 billion by 2050 (WHO). In the USA, ...
    • Aging: a portrait from gene expression profile in blood cells 

      Calabria, Elisa; Mazza, Emilia Maria Cristina; Dyar, Kenneth Allen; Pogliaghi, Silvia; Bruseghini, Paolo; Morandi, Carlo; Salvagno, Gian Luca; Gelati, Matteo; Guidi, Gian Cesare; Bicciato, Silvio; Schiaffino, Stefano; Schena, Frederico; Capelli, Carlo (Journal article; Peer reviewed, 2016-08-19)
      The availability of reliable biomarkers of aging is important not only to monitor the effect of interventions and predict the timing of pathologies associated with aging but also to understand the mechanisms and devise ...
    • Alpine skiing with total knee arthroplasty (ASWAP): muscular adaptations 

      Rieder, Florian; Kösters, Alexander; Wiesinger, Hans-Peter; Dorn, U.; Hofstaedter, T.; Fink, Christian; Müller, Erich; Seynnes, Olivier R. (Journal article; Peer reviewed, 2015-06-17)
      This study investigated the effectiveness of recreational skiing as an intervention to improve quadriceps muscle architecture, strength, and antagonistic co-activation in patients with unilateral total knee arthroplasty ...
    • Antioxidant enzymes and Nrf2/Keap1 in human skeletal muscle: Influence of age, sex, adiposity and aerobic fitness 

      Galvan-Alvarez, Victor; Gallego-Selles, Angel; Martinez-Canton, Miriam; García-Gonzalez, Eduardo; Gelabert-Rebato, Miriam; Ponce-Gonzalez, Jesus Gustavo; Larsen, Steen; Morales-Alamo, David; Losa-Reyna, Jose; Perez-Suarez, Ismael; Dorado, Cecilia; Perez-Valera, Mario; Holmberg, Hans-Christer; Boushel, Robert; Velasco, Pedro de Pablos; Helge, Jørn Wulff; Martin-Rincon, Marcos; Calbet, José Antonio López (Peer reviewed; Journal article, 2023)
      Ageing, a sedentary lifestyle, and obesity are associated with increased oxidative stress, while regular exercise is associated with an increased antioxidant capacity in trained skeletal muscles. Whether a higher aerobic ...
    • Association of accelerometer-derived step volume and intensity with hospitalizations and mortality in older adults: A prospective cohort study 

      Mañas, Asier; del Pozo-Cruz, Borja; Ekelund, Ulf; Reyna, José Losa; Gómez, Irene Rodríguez; Carreño, José Antonio Carnicero; Mañas, Leocadio Rodríguez; Ara, Ignacio; García-García, Francisco J. (Peer reviewed; Journal article, 2021)
      Purpose: To examine the associations of accelerometer-derived steps volume and intensity with hospitalizations and all-cause mortality in older adults. Methods: This prospective cohort study involved 768 community-dwelling ...
    • Effectiveness of individualized training based on force: Velocity profiling on physical function in older men 

      Lindberg, Kolbjørn Andreas; Lohne-Seiler, Hilde; Fosstveit, Sindre Herskedal; Sibayan, Erlend E.; Fjeller, Joachim S.; Løvold, Sondre; Kolnes, Tommy M.; Vårvik, Fredrik Tonstad; Berntsen, Sveinung; Paulsen, Gøran; Seynnes, Olivier R.; Bjørnsen, Thomas (Peer reviewed; Journal article, 2022)
      The study aimed to investigate the effectiveness of an individualized power training program based on force–velocity (FV) profiling on physical function, muscle morphology, and neuromuscular adaptations in older men. ...
    • Effects of acute and chronic strength training on skeletal muscle autophagy in frail elderly men and women 

      Aas, Sigve Nyvik; Tømmerbakke, Daniel; Godager, Sindre; Nordseth, Martin; Armani, Andrea; Sandri, Marco; Benestad, Haakon Breien; Raastad, Truls (Peer reviewed; Journal article, 2020)
      Aging is associated with alterations in skeletal muscle autophagy, potentially affecting both muscle mass and quality in a negative manner. Strength training with protein supplementation has been reported to improve both ...
    • Effects of High-Intensity Interval Training and Isoinertial Training on Leg Extensors Muscle Function, Structure, and Intermuscular Adipose Tissue in Older Adults 

      Bruseghini, Paolo; Capelli, Carlo; Calabria, Elisa; Rossi, Andrea; Tam, Enrico (Peer reviewed; Journal article, 2019)
      We compared the effects of aerobic high-intensity training (HIT) and isoinertial resistance training (IRT) on the strength, mass, architecture, intermuscular adipose tissue (IMAT) quality, and neuromuscular activation of ...
    • Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle 

      Voisin, Sarah; Seale, Kirsten; Jacques, Macsue; Landen, Shanie; Coffey, Vernon G.; Walsh, Colum; Davison, Gareth; McBride, Catherine; Irwin, Rachelle; Hansson, Ola; Asplund, Olof; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Ashton, Kevin J.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Lindholm, Maléne E.; Sharples, Adam P.; Eynon, Nir (Peer reviewed; Journal article, 2023)
      Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training ...
    • Muscular HSP70 content is higher in elderly compared to young, but is normalized after 12 weeks of strength training 

      Cumming, Kristoffer Toldnes; Kvamme, Nils Helge; Schaad, Laura; Ugelstad, Ingrid; Raastad, Truls (Peer reviewed; Journal article, 2021)
      Purpose: Aging is associated with increased myocellular stress and loss of muscle mass and function. Heat shock proteins (HSPs) are upregulated during periods of stress as part of the cells protective system. Exercise can ...
    • Objectively Measured Physical Activity and Polypharmacy Among Brazilian Community-Dwelling Older Adults 

      Bielemann, Renata M.; Silveira, Marysabel P. T.; Lutz, Bárbara H.; Miranda, Vanessa I. A.; Gonzalez, Maria Cristina; Brage, Soren; Ekelund, Ulf; Bertoldi, Andréa D. (Peer reviewed; Journal article, 2020)
      Background: Previous observations regarding association between physical activity (PA) and use of medicines among older adults are derived from self-reported PA. This study aimed to evaluate the association between objectively ...
    • The relationship between the relative age effect and performance among athletes in World Handball Championships 

      De La Rubia, Alfonso; Bjørndal, Christian T.; Sánchez-Molina, Joaquín; Yagüe, José María; Calvo, Jorge Lorenzo; Maroto-Izquierdo, Sergio (Peer reviewed; Journal article, 2020)
      This study examines the relative age effect (RAE) and its impact on the performance of elite male (n = 3,358) and female (n = 3,273) handball players in the U-19 (n = 2,188), U-21 (n = 2,031), and senior (n = 2,412) ...
    • Resistance training rejuvenates the mitochondrial methylome in aged human skeletal muscle 

      Ruple, Bradley A; Godwin, Joshua S.; Mesquita, Paulo H. C; Osburn, Shelby C; Vann, Christopher G; Lamb, Donald A; Sexton, Casey L; Candow, Darren G; Forbes, Scott C; Frugé, Andrew D.; Kavazis, Andreas N; Young, Kaelin C; Seaborne, Robert A.; Sharples, Adam; Roberts, Michael D (Peer reviewed; Journal article, 2021)
      Resistance training (RT) dynamically alters the skeletal muscle nuclear DNA methylome. However, no study has examined if RT affects the mitochondrial DNA (mtDNA) methylome. Herein, ten older, Caucasian untrained males (65 ...
    • Stability and change in screen-based sedentary behaviours and associated factors among Norwegian children in the transition between childhood and adolescence 

      Gebremariam, Mekdes K.; Totland, Torunn Holm; Andersen, Lene F.; Bergh, Ingunn Holden; Bjelland, Mona; Grydeland, May; Ommundsen, Yngvar; Lien, Nanna (Journal article; Peer reviewed, 2012-02-06)
      Background: In order to inform interventions to prevent sedentariness, more longitudinal studies are needed focusing on stability and change over time in multiple sedentary behaviours. This paper investigates patterns ...