• Exercise mitigates the loss of muscle mass by attenuating the activation of autophagy during severe energy deficit 

      Martin-Rincon, Marcos; Pérez-López, Antonio; Morales-Alamo, David; Perez-Suarez, Ismael; de Pablos-Velasco, Pedro; Perez-Valera, Mario; Perez-Regalado, Sergio; Martinez-Canton, Miriam; Gelabert-Rebato, Miriam; Juan-Habib, Julian William; Holmberg, Hans-Christer; Calbet, Jose Antonio Lopez (Peer reviewed; Journal article, 2019)
      The loss of skeletal muscle mass with energy deficit is thought to be due to protein breakdown by the autophagy-lysosome and the ubiquitin-proteasome systems. We studied the main signaling pathways through which exercise ...
    • Heat shock protein translocation and expression response is attenuated in response to repeated eccentric exercise 

      Vissing, Kristian; Bayer, Monica; Overgaard, Kristian; Schjerling, Peter; Raastad, Truls (Peer reviewed; Journal article, 2008-11-20)
      Aim: This study hypothesized that heat shock protein (HSP) translocation and upregulation is more probable to occur after eccentric exercise than after concentric exercise or repeated eccentric exercise. Methods: Fourteen ...
    • Ubiquitin ligases in longevity and aging skeletal muscle 

      Hughes, David C.; Baehr, Leslie M.; Waddell, David S.; Sharples, Adam; Bodine, Sue C. (Peer reviewed; Journal article, 2022)
      The development and prevalence of diseases associated with aging presents a global health burden on society. One hallmark of aging is the loss of proteostasis which is caused in part by alterations to the ubiquitin–proteasome ...