Blar i Artikler / Articles på emneord "DNA methylation"

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    • The comparative methylome and transcriptome after change of direction compared to straight line running exercise in human skeletal muscle 

      Massar, Mohd Firdaus; Turner, Daniel C.; Gorski, Piotr Patryk; Seaborne, Robert A.; Strauss, Juliette A.; Shepherd, Sam O.; Cocks, Matt; Zierath, Juleen R.; Drust, Barry; Pillon, Nicolas J.; Hulton, Andrew T.; Sharples, Adam P. (Peer reviewed; Journal article, 2021)
      The methylome and transcriptome signatures following exercise that are physiologically and metabolically relevant to sporting contexts such as team sports or health prescription scenarios (e.g., high intensity interval ...

    • DNA methylation across the genome in aged human skeletal muscle tissue and muscle‑derived cells: The role of HOX genes and physical activity 

      Turner, Daniel C.; Gorski, Piotr Patryk; Massar, Mohd Firdaus; Seaborne, Robert A.; Baumert, Phillipp; Brown, Alexander D.; Erskine, Robert M.; Dos-Remedios, Ian; Voisin, Sarah; Eynon, Nir; Borisov, Oleg; Larin, Andrey; Semenova, Ekaterina A.; Popov, Daniil; Drust, Barry; Owens, Daniel J.; Ahmetov, Ildus I.; Sharples, Adam; Kitchen, Mark O.; Sultanov, R. I.; Generozov, Edward V.; Stewart, Claire E. (Peer reviewed; Journal article, 2020)
      Skeletal muscle tissue demonstrates global hypermethylation with age. However, methylome changes across the time-course of differentiation in aged human muscle derived cells, and larger coverage arrays in aged muscle tissue ...

    • An epigenetic clock for human skeletal muscle 

      Voisin, Sarah; Harvey, Nicholas R; Haupt, Larisa M; Griffiths, Lyn R; Aston, Kevin J; Coffey, Vernon G.; Doering, Thomas M; Thompson, Jamie-Lee M; Benedict, Christian; Cedernaes, Jonathan; Lindholm, Malene E; Craig, Jeffrey M; Rowlands, David S; Sharples, Adam; Horvath, Steve; Eynon, Nir (Peer reviewed; Journal article, 2020)
      Background: Ageing is associated with DNA methylation changes in all human tissues, and epigenetic markers can estimate chronological age based on DNA methylation patterns across tissues. However, the construction of the ...

    • Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism 

      Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen; Thoresen, G. Hege (Peer reviewed; Journal article, 2017)
      Background and aims: Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in vitro metabolic adaptations by studying ...

    • Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle 

      Voisin, Sarah; Seale, Kirsten; Jacques, Macsue; Landen, Shanie; Coffey, Vernon G.; Walsh, Colum; Davison, Gareth; McBride, Catherine; Irwin, Rachelle; Hansson, Ola; Asplund, Olof; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Ashton, Kevin J.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Lindholm, Maléne E.; Sharples, Adam P.; Eynon, Nir (Peer reviewed; Journal article, 2023)
      Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training ...

    • Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo 

      Turner, Daniel C.; Gorski, Piotr Patryk; Seaborne, Robert A.; Viggars, Mark; Murphy, Mark; Jarvis, Jonathan C.; Martin, Neil R. W.; Stewart, Claire E.; Sharples, Adam P. (Peer reviewed; Journal article, 2021)
      Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of ...

    • Meta-analysis of genome-wide DNA methylation and integrative omics of age in human skeletal muscle 

      Voisin, Sarah; Jacques, Macsue; Landen, Shanie; Harvey, Nicholas R.; Haupt, Larisa M.; Griffiths, Lyn R.; Gancheva, Sofiya; Ouni, Meriem; Jähnert, Marcus; Ashton, Kevin J.; Coffey, Vernon G.; Thompson, Jamie-Lee M.; Doering, Thomas M.; Gabory, Anne; Junien, Claudine; Caiazzo, Robert; Verkindt, Hélène; Raverdy, Violetta; Pattou, Francois; Froguel, Philippe; Blocquiaux, Sara; Thomis, Martine; Roden, Michael; Horvath, Steve; Eynon, Nir; Craig, Jeffrey M.; Sharples, Adam P.; Schürmann, Annette (Peer reviewed; Journal article, 2021)
      Background Knowledge of age-related DNA methylation changes in skeletal muscle is limited, yet this tissue is severely affected by ageing in humans. Methods We conducted a large-scale epigenome-wide association ...

    • Skeletal muscle DNA methylation and mRNA responses to a bout of higher versus lower load resistance exercise in previously trained men 

      Sexton, Casey L.; McIntosh, Mason C.; Ruple, Bradley A.; Osburn, Shelby C.; Hollingsworth, Blake R.; Kontos, Nicholas J.; Agostinelli, Philip J.; Kavazis, Andreas N.; Ziegenfuss, Tim N.; Lopez, Hector L.; Young, Kaelin C.; Dwaraka, Varun B.; Mobley, Christopher B.; Sharples, Adam P.; Godwin, Joshua S.; Smith, Ryan; Frugé, Andrew D.; Roberts, Michael D. (Peer reviewed; Journal article, 2023)
      We sought to determine the skeletal muscle genome-wide DNA methylation and mRNA responses to one bout of lower load (LL) versus higher load (HL) resistance exercise. Trained college-aged males (n = 11, 23 ± 4 years old, 4 ...