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dc.contributor.authorAndersen, Lars Bo
dc.contributor.authorMüller, Klaus
dc.contributor.authorEiberg, Stig
dc.contributor.authorFroberg, Karsten
dc.contributor.authorAndersen, Johnny Fredsbo Børm
dc.contributor.authorBugge, Anna
dc.contributor.authorHermansen, Bianca El-Namaan
dc.contributor.authorMcMurray, Robert G.
dc.date.accessioned2010-08-16T11:17:08Z
dc.date.available2010-08-16T11:17:08Z
dc.date.issued2010-04
dc.identifierSeksjon for idrettsmedisinske fag / Department of Sports Medicine
dc.identifier.citationMetabolism. 2010, 59(4), 561-566en_US
dc.identifier.issn0026-0495
dc.identifier.urihttp://hdl.handle.net/11250/170625
dc.descriptionI Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på www.sciencedirect.com: http://dx.doi.org/10.1016/j.metabol.2009.08.019 / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The original publication is available at www.sciencedirect.com: http://dx.doi.org/10.1016/j.metabol.2009.08.019en_US
dc.description.abstractThe aim was to evaluate the possible role of tumor necrosis factor α (TNF-α), interleukin-6 (IL-6), C-reactive protein (CRP), low fitness, and fatness in the early development of clustering of cardiovascular disease (CVD) risk factors and insulin resistance. Subjects for this cross-sectional study were obtained from 18 schools near Copenhagen, Denmark. Two hundred ten 9-year-old children were selected for cytokine analysis from 434 third-grade children with complete CVD risk profiles. The subgroup was selected according to the CVD risk factor profile (upper and lower quartile of a composite CVD risk score). All the CVD risk factors and CRP differed between the high- and low-risk groups; but plasma glucose, TNF-α, and IL-6 had small and inconsistent differences. Strong associations were found between CVD risk scores and fitness (VO2peak) or fatness. No associations were found between CVD risk scores and TNF-α and IL-6. C-reactive protein was associated with fitness, fatness, and CVD risk score. This study does not support an association between plasma IL-6 or TNF-α and low insulin sensitivity or clustering of CVD risk factors in a young cohort. Inflammation was more pronounced in fat and unfit children based on the association with CRP levels. The association between fitness and fatness variables, insulin resistance, and clustered risk could be caused by other mechanisms related to these exposures. The role of IL-6 remains unclear.en_US
dc.language.isoengen_US
dc.publisherElsevieren_US
dc.subjectc-reactive proteinen_US
dc.subjectanalysisen_US
dc.subjectcardiovascular diseasesen_US
dc.subjectchilden_US
dc.subjectinsulin resistanceen_US
dc.subjectinterleukin-6en_US
dc.subjectlogistic modelsen_US
dc.subjectrisk factorsen_US
dc.subjecttumor necrosis factor-alphaen_US
dc.titleCytokines and clustered cardiovascular risk factors in childrenen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.subject.nsiVDP::Medical disciplines: 700en_US
dc.source.pagenumber561-566en_US


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