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dc.contributor.authorMunkvik, Morten
dc.contributor.authorRehn, Tommy A.
dc.contributor.authorSlettaløkken, Gunnar
dc.contributor.authorHasic, Almira
dc.contributor.authorHallén, Jostein
dc.contributor.authorSjaastad, Ivar
dc.contributor.authorSejersted, Ole M.
dc.contributor.authorLunde, Per Kristian
dc.date.accessioned2011-05-02T11:47:25Z
dc.date.available2011-05-02T11:47:25Z
dc.date.issued2010-05
dc.identifierSeksjon for fysisk prestasjonsevne / Department of Physical Performance
dc.identifier.citationMedicine & Science in Sports & Exercise. 2010, 42(5), 847-855en_US
dc.identifier.issn0195-9131
dc.identifier.urihttp://hdl.handle.net/11250/170809
dc.descriptionI Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på www.ovid.com: http://dx.doi.org/10.1249/MSS.0b013e3181c29ec1 / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The definitive version is available at www.ovid.com: http://dx.doi.org/10.1249/MSS.0b013e3181c29ec1en_US
dc.description.abstractPurpose: Patients with chronic heart failure (CHF) typically complain about skeletal muscle fatigue. In rat experiments, reduced intracellular calcium release seems to be related to fatigue development in normal skeletal muscle but not in muscle from rats with CHF. We therefore hypothesize that training may not improve intracellular calcium cycling to the same extent in muscles from patients with CHF compared with healthy controls (HC). Methods: Thirteen HC and 11 CHF patients performed 6 wk of unilateral knee extensor endurance training. Computed tomographic examinations of the thigh and biopsies of vastus lateralis were obtained bilaterally before and after the training period. Results: Peak power of the trained leg was 10% and 14% greater than that in the untrained leg in HC and CHF, respectively. For the HC, training resulted in a higher Ca2+ release rate and a lower leak in the trained leg associated with a tendency of increased ryanodine receptor (RyR) content with reduced phosphorylation level. In the trained leg of CHF patients, RyR content was reduced without associated changes of either Ca2+ leak or release rate. Conclusions: Training in HC has an effect on Ca2+ leak and release of the sarcoplasmic reticulum, but in CHF patients, training is achieved without such changes. Thus, calcium handling seems not to be the site of decreased exercise tolerance in CHF.en_US
dc.language.isoengen_US
dc.publisherWolters Kluweren_US
dc.subjectsarcoplasmic reticulumen_US
dc.subjectknee extensoren_US
dc.subjectmaleen_US
dc.subjectcitrate synthaseen_US
dc.subjectcomputed tomographyen_US
dc.subjectmhc isoformen_US
dc.titleTraining effects on skeletal muscle calcium handling in human chronic heart failureen_US
dc.typeJournal articleen_US
dc.typePeer revieweden_US
dc.subject.nsiVDP::Social science: 200::Social science in sports: 330::Other subjects within physical education: 339en_US
dc.source.pagenumber847-855en_US


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