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dc.contributor.authorKolsgaard, Magnhild L Pollestad
dc.contributor.authorJoner, Geir
dc.contributor.authorBrunborg, Cathrine
dc.contributor.authorAnderssen, Sigmund A.
dc.contributor.authorTonstad, Serena
dc.contributor.authorAndersen, Lene F.
dc.date.accessioned2012-04-11T07:08:41Z
dc.date.available2012-04-11T07:08:41Z
dc.date.issued2011-05-27
dc.identifierSeksjon for idrettsmedisinske fag / Department of Sports Medicine
dc.identifier.citationBMC Pediatrics. 2011. 11:47no_NO
dc.identifier.issn1471-2431
dc.identifier.urihttp://hdl.handle.net/11250/170839
dc.description© 2011 Pollestad Kolsgaard et al; licensee BioMed Central Ltd.no_NO
dc.description.abstractBackground: Weight loss and increased physical fitness are established approaches to reduce cardiovascular risk factors. We studied the reduction in BMI z-score associated with improvement in cardiometabolic risk factors in overweight and obese children and adolescents treated with a combined hospital/public health nurse model. We also examined how aerobic fitness influenced the results. Methods: From 2004-2007, 307 overweight and obese children and adolescents aged 7-17 years were referred to an outpatient hospital pediatrics clinic and evaluated by a multidisciplinary team. Together with family members, they were counseled regarding diet and physical activity at biannual clinic visits. Visits with the public health nurse at local schools or at maternal and child health centres were scheduled between the hospital consultations. Fasting blood samples were taken at baseline and after one year, and aerobic fitness (VO2peak) was measured. In the analyses, 230 subjects completing one year of follow-up by December 2008 were divided into four groups according to changes in BMI z-score: Group 1: decrease in BMI z-score≥0.23, Group 2: decrease in BMI z-score≥0.1-< 0.23, Group 3: decrease in/stable BMI z-score≥0.0-< 0.1, Group 4: increase in BMI z-score (>0.00-0.55). Results: 230 participants were included in the analyses (75%). Mean (SD) BMI z-score was reduced from 2.18 (0.30) to 2.05 (0.39) (p < 0.001) in the group as a whole. After adjustment for BMI z-score, waist circumference and gender, the three groups with reduced BMI z-score had a significantly greater reduction in HOMA-IR, insulin, total cholesterol, LDL cholesterol and total/HDL cholesterol ratio than the group with increased BMI z-score. Adding change in aerobic fitness to the model had little influence on the results. Even a very small reduction in BMI z-score (group 3) was associated with significantly lower insulin, total cholesterol, LDL and total/HDL cholesterol ratio. The group with the largest reduction in BMI z-score had improvements in HOMA-IR and aerobic fitness as well. An increase in BMI z-score was associated with worsening of C-peptide and total/HDL cholesterol ratio. Conclusions: Even a modest reduction in BMI z-score after one year of combined hospital/and public health nurse intervention was associated with improvement in several cardiovascular risk factors.no_NO
dc.language.isoengno_NO
dc.publisherBioMed Centralno_NO
dc.subjectadolescentno_NO
dc.subjectBody Mass Indexno_NO
dc.subjectcardiovascular diseasesno_NO
dc.subjectchildno_NO
dc.subjectcombined modality therapyno_NO
dc.subjectdietno_NO
dc.subjectfemaleno_NO
dc.subjectfollow-up studiesno_NO
dc.subjectmaleno_NO
dc.subjectobesityno_NO
dc.subjectoutpatientsno_NO
dc.subjectoverweightno_NO
dc.subjecttherapyno_NO
dc.subjectphysical fitnessno_NO
dc.subjectpublic health nursingno_NO
dc.subjectrisk factorsno_NO
dc.subjecttreatment outcomeno_NO
dc.subjectweight lossno_NO
dc.titleReduction in BMI z-score and improvement in cardiometabolic risk factors in obese children and adolescents. The Oslo Adiposity Intervention Study - a hospital/public health nurse combined treatmentno_NO
dc.typeJournal articleno_NO
dc.typePeer reviewedno_NO
dc.subject.nsiVDP::Medical disciplines: 700::Basic medical, dental and veterinary science disciplines: 710no_NO
dc.subject.nsiVDP::Medical disciplines: 700::Clinical medical disciplines: 750no_NO
dc.source.volume11no_NO
dc.source.journalBMC Pediatricsno_NO


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