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dc.contributor.authorCalabria, Elisa
dc.contributor.authorMazza, Emilia Maria Cristina
dc.contributor.authorDyar, Kenneth Allen
dc.contributor.authorPogliaghi, Silvia
dc.contributor.authorBruseghini, Paolo
dc.contributor.authorMorandi, Carlo
dc.contributor.authorSalvagno, Gian Luca
dc.contributor.authorGelati, Matteo
dc.contributor.authorGuidi, Gian Cesare
dc.contributor.authorBicciato, Silvio
dc.contributor.authorSchiaffino, Stefano
dc.contributor.authorSchena, Frederico
dc.contributor.authorCapelli, Carlo
dc.date.accessioned2017-01-31T12:28:36Z
dc.date.available2017-01-31T12:28:36Z
dc.date.issued2016-08-19
dc.identifier.citationAging. 2016, 8, 1802-1821nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/2429046
dc.description.abstractThe availability of reliable biomarkers of aging is important not only to monitor the effect of interventions and predict the timing of pathologies associated with aging but also to understand the mechanisms and devise appropriate countermeasures. Blood cells provide an easily available tissue and gene expression profiles from whole blood samples appear to mirror disease states and some aspects of the aging process itself. We report here a microarray analysis of whole blood samples from two cohorts of healthy adult and elderly subjects, aged 43±3 and 68±4 years, respectively, to monitor gene expression changes in the initial phase of the senescence process. A number of significant changes were found in the elderly compared to the adult group, including decreased levels of transcripts coding for components of the mitochondrial respiratory chain, which correlate with a parallel decline in the maximum rate of oxygen consumption (VO2max), as monitored in the same subjects. In addition, blood cells show age-related changes in the expression of several markers of immunosenescence, inflammation and oxidative stress. These findings support the notion that the immune system has a major role in tissue homeostasis and repair, which appears to be impaired since early stages of the aging process.nb_NO
dc.language.isoengnb_NO
dc.publisherImpact Journalsnb_NO
dc.subjectagingnb_NO
dc.subjectimmunosenescencenb_NO
dc.subjectmicroarraynb_NO
dc.subjectblood cellsnb_NO
dc.subjectexercisenb_NO
dc.titleAging: a portrait from gene expression profile in blood cellsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750::Geriatri: 778nb_NO
dc.source.journalAgingnb_NO
dc.identifier.doi10.18632/aging.101016
dc.description.localcodeSeksjon for fysisk prestasjonsevne / Department of Physical Performancenb_NO


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