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dc.contributor.authorEngen, Cathrine Nørstad
dc.contributor.authorLøken, Sverre
dc.contributor.authorÅrøen, Asbjørn
dc.contributor.authorHo, Charles
dc.contributor.authorEngebretsen, Lars
dc.date.accessioned2017-01-31T14:30:48Z
dc.date.available2017-01-31T14:30:48Z
dc.date.issued2016-11-24
dc.identifier.citationActa Orthopaedica. 2017, 88, 82-89nb_NO
dc.identifier.urihttp://hdl.handle.net/11250/2429081
dc.description.abstractBackground and purpose: The natural history of focal cartilage defects (FCDs) is still unresolved, as is the long-term cartilage quality after cartilage surgery. It has been suggested that delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) is a biomarker of early OA. We aimed to quantitatively evaluate the articular cartilage in knees with FCDs, 12 years after arthroscopic diagnosis. Patients and methods: We included 21 patients from a cohort of patients with knee pain who underwent arthroscopy in 1999. Patients with a full-thickness cartilage defect, stable knees, and at least 50% of both their menisci intact at baseline were eligible. 10 patients had cartilage repair performed at baseline (microfracture or autologous chondrocyte implantation), whereas 11 patients had either no additional surgery or simple debridement performed. Mean follow-up time was 12 (10–13) years. The morphology and biochemical features were evaluated with dGEMRIC and T2 mapping. Standing radiographs for Kellgren and Lawrence (K&L) classification of osteoarthritis (OA) were obtained. Knee function was assessed with VAS, Tegner, Lysholm, and KOOS. Results: The dGEMRIC showed varying results but, overall, no increased degeneration of the injured knees. Degenerative changes (K&L above 0) were, however, evident in 13 of the 21 knees. Interpretation: The natural history of untreated FCDs shows large dGEMRIC variations, as does the knee articular cartilage of surgically treated patients. In this study, radiographic OA changes did not correlate with cartilage quality, as assessed with dGEMRIC.nb_NO
dc.language.isoengnb_NO
dc.publisherTaylor & Francisnb_NO
dc.subjectadolescent
dc.subjectadult
dc.subjectarthroscopy
dc.subjectcartilage diseases/diagnosis/*etiology
dc.subjectcartilage, articular/*diagnostic imaging
dc.subjectchild
dc.subjectfemale
dc.subjectfollow-up studies
dc.subject*forecasting
dc.subjecthumans
dc.subjectknee joint/diagnostic imaging/*surgery
dc.subjectmagnetic resonance imaging/*methods
dc.subjectmale
dc.subjectosteoarthritis, knee/diagnosis/*surgery
dc.subjectretrospective studies
dc.subjectyoung adult
dc.titleNo degeneration found in focal cartilage defects evaluated with dGEMRIC at 12-year follow-upnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.subject.nsiVDP::Medisinske Fag: 700::Klinisk medisinske fag: 750nb_NO
dc.source.journalActa Orthopaedicanb_NO
dc.identifier.doihttp://dx.doi.org/10.1080/17453674.2016.1255484
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sports Medicinenb_NO


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