dc.contributor.author | Guo, Vivianyawei | |
dc.contributor.author | Brage, Søren | |
dc.contributor.author | Ekelund, Ulf | |
dc.contributor.author | Griffin, Simon J. | |
dc.contributor.author | Simmons, Rebecca K. | |
dc.date.accessioned | 2017-03-07T08:21:49Z | |
dc.date.available | 2017-03-07T08:21:49Z | |
dc.date.issued | 2015-09-08 | |
dc.identifier.citation | Diabetic Medicine. 2016, 33, 1222-1229 | nb_NO |
dc.identifier.uri | http://hdl.handle.net/11250/2433050 | |
dc.description.abstract | Aim: To assess the prospective association between objectively measured physical activity and kidney function over 4 years in people with Type 2 diabetes. Methods: Individuals (120 women and 206 men) participating in the ADDITION-Plus trial underwent assessment of sedentary time (SED-time), time spent in moderate-to-vigorous-intensity physical activity (MVPA) and total physical activity energy expenditure (PAEE) using a combined heart rate and movement sensor, and kidney function [estimated glomerular filtration rate (eGFR), serum creatinine and urine albumin-to-creatinine ratio (ACR)] at baseline and after 4 years of follow-up. Multivariate regression was used to quantify the association between change in SED-time, MVPA and PAEE and kidney measures at four-year follow-up, adjusting for change in current smoking status, waist circumference, HbA1c, systolic blood pressure, triglycerides and medication usage. Results: Over 4 years, there was a decline in eGFR values from 87.3 to 81.7 ml/min/1.73m2 (P < 0.001); the prevalence of reduced eGFR (eGFR < 60 ml/min/1.73m2) increased from 6.1 to 13.2% (P < 0.001). There were small increases in serum creatinine (median: 81–84 μmol/l, P < 0.001) and urine ACR (median: 0.9–1.0 mg/mmol, P = 0.005). Increases in SED-time were associated with increases in serum creatinine after adjustment for MVPA and cardiovascular risk factors (β = 0.013, 95% CI: 0.001, 0.03). Conversely, increases in PAEE were associated with reductions in serum creatinine (β = –0.001, 95% CI: –0.003, –0.0001). Conclusion: Reducing time spent sedentary and increasing overall physical activity may offer intervention opportunities to improve kidney function among individuals with diabetes. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Wiley | nb_NO |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | albuminuria/urine | |
dc.subject | cohort studies | |
dc.subject | creatinine/blood/urine | |
dc.subject | diabetes mellitus, type 2/drug therapy/*metabolism | |
dc.subject | disease progression | |
dc.subject | energy metabolism | |
dc.subject | exercise | |
dc.subject | female | |
dc.subject | follow-up studies | |
dc.subject | glomerular filtration rate | |
dc.subject | humans | |
dc.subject | hypoglycemic agents/therapeutic use | |
dc.subject | linear models | |
dc.subject | logistic models | |
dc.subject | male | |
dc.subject | middle aged | |
dc.subject | multivariate analysis | |
dc.subject | prospective studies | |
dc.subject | renal insufficiency, chronic/*metabolism | |
dc.subject | sedentary lifestyle | |
dc.subject | time factors | |
dc.subject | adult | |
dc.subject | aged | |
dc.subject | albuminuria/urine | |
dc.subject | cohort studies | |
dc.subject | creatinine/blood/urine | |
dc.subject | diabetes mellitus, type 2/drug therapy/*metabolism | |
dc.subject | disease progression | |
dc.subject | energy metabolism | |
dc.subject | exercise | |
dc.subject | female | |
dc.subject | follow-up studies | |
dc.subject | glomerular filtration rate | |
dc.subject | humans | |
dc.subject | hypoglycemic agents/therapeutic use | |
dc.subject | linear models | |
dc.subject | logistic models | |
dc.subject | male | |
dc.subject | middle aged | |
dc.subject | multivariate analysis | |
dc.subject | prospective studies | |
dc.subject | renal insufficiency, chronic/*metabolism | |
dc.subject | sedentary lifestyle | |
dc.subject | time factors | |
dc.title | Objectively measured sedentary time, physical activity and kidney function in people with recently diagnosed Type 2 diabetes: a prospective cohort analysis | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.subject.nsi | VDP::Medisinske Fag: 700 | nb_NO |
dc.source.journal | Diabetic Medicine | nb_NO |
dc.identifier.doi | 10.1111/dme.12886 | |
dc.description.localcode | Seksjon for idrettsmedisinske fag / Department of Sports Medicine | nb_NO |