dc.contributor.author | Færch, Kristine | |
dc.contributor.author | Witte, Rinse Daniel | |
dc.contributor.author | Brunner, Eric John | |
dc.contributor.author | Kivimäki, Mika | |
dc.contributor.author | Tabak, Adam | |
dc.contributor.author | Jørgensen, Marit Eika | |
dc.contributor.author | Ekelund, Ulf | |
dc.contributor.author | Vistisen, Dorte | |
dc.date.accessioned | 2017-12-11T12:55:53Z | |
dc.date.available | 2017-12-11T12:55:53Z | |
dc.date.issued | 2017-07-26 | |
dc.identifier.citation | Journal of Clinical Endocrinology and Metabolism. 2017, 102, 3712-3721 | nb_NO |
dc.identifier.uri | http://hdl.handle.net/11250/2470294 | |
dc.description.abstract | Context: The effects of physical activity (PA) on improvement of glycemia may differ between prediabetic individuals defined by oral glucose tolerance test vs glycated hemoglobin (HbA1c). Objective: We studied the association between PA and improvement of glycemia in individuals with prediabetes defined by glucose vs HbA1c criteria. Design, Setting, and Participants: From the Whitehall II study, 957 participants ith prediabetes defined by isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), or both and 457 with prediabetes defined by HbA1c were included. Main Outcome Measures: The associations of PA with concomitant changes n glucose-related outcomes during 5 years of follow-up were analyzed. A recursive partitioning analysis was performed to study heterogeneity in the association between baseline PA and the prob ability of reversion to normoglycemia. Results: After 5 years of follow-up, 405 (42%) individuals with glucose-defined prediabetes reverted to normal glucose tolerance (NGT). A 5-year increase in moderate-to-vigorous-intensity PA was associated with improvements in insulin sensitivity and b-cell function, but PA was not generally associated with reversion to NGT. Only among women $50 years with i-IFG or i-IGT, higher amounts of PA were associated with higher probability of reversion to NGT. InHbA1c-defined prediabetes, only 20 individuals (4.4%) reverted to normoglycemia, and PA was not associated with improvement in glycemic markers. Conclusions: PA may be particularly important for reversion to normoglycemia among older women with i-IFG or i-IGT. Individuals with prediabetes identified by HbA1c have a low probability of reversion to normoglycemia, and their changes in glycemia are not related to PA. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Oxford University Press | nb_NO |
dc.subject | aged | nb_NO |
dc.subject | blood glucose/*analysis/metabolism | nb_NO |
dc.subject | cohort studies | nb_NO |
dc.subject | exercise/*physiology | nb_NO |
dc.subject | female | nb_NO |
dc.subject | follow-up studies | nb_NO |
dc.subject | glucose intolerance/blood/*diagnosis | nb_NO |
dc.subject | glucose tolerance test/classification/methods | nb_NO |
dc.subject | glycated hemoglobin A/analysis/metabolism | nb_NO |
dc.subject | humans | nb_NO |
dc.subject | male | nb_NO |
dc.subject | middle aged | nb_NO |
dc.subject | prediabetic state/*blood/*diagnosis | nb_NO |
dc.title | Physical activity and improvement of glycemia in prediabetes by different diagnostic criteria | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.description.version | publishedVersion | nb_NO |
dc.rights.holder | This article has been published under the terms of the Creative Commons Attribution License (CC BY; https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Copyright for this article is retained by the author(s). | nb_NO |
dc.source.journal | Journal of Clinical Endocrinology and Metabolism (JCEM) | nb_NO |
dc.identifier.doi | 10.1210/jc.2017-00990 | |
dc.description.localcode | Seksjon for idrettsmedisinske fag / Department of Sport Medicine | nb_NO |