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dc.contributor.authorDencker, Magnus
dc.contributor.authorTanha, Tina
dc.contributor.authorKarlsson, Magnus K.
dc.contributor.authorWollmer, Per
dc.contributor.authorAndersen, Lars Bo
dc.contributor.authorThorsson, Ola
dc.date.accessioned2018-04-11T10:15:54Z
dc.date.available2018-04-11T10:15:54Z
dc.date.created2017-12-27T17:39:15Z
dc.date.issued2017
dc.identifier.citationPLoS ONE. 2017, 12, e0187494
dc.identifier.issn1932-6203
dc.identifier.urihttp://hdl.handle.net/11250/2493598
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
dc.description.abstractObjective: This study investigated potential associations between novel biomarkers for cardiovascular disease and other surrogate markers for health. Methods: Community sample of 170 (92 boys and 78 girls) children aged 8–11 years. Total fat mass (TBF) and abdominal fat (AFM) were measured by Dual-energy x-ray absorptiometry (DXA). Total body fat was also expressed as percentage of total body mass (BF%), and body fat distribution was calculated as AFM/TBF. Maximal oxygen uptake (VO2PEAK), systolic and diastolic blood pressure (SBP and DBP) and pulse pressure (PP) were measured. Echocardiography was performed. Left atrial size (LA) and left ventricular mass (LVM) were measured. A follow-up DXA scan was available in 152 children (84 boys and 68 girls). Frozen serum samples were analyzed for cystatin B, cathepsin L and cathepsin D. Results: Partial correlations between cystatin B versus lnTBF, lnBF%, lnAFM, AFM/TBF, VO2PEAK and PP were; r = 0.38, 0.36, 0.38, 0.29, -0.25 and 0.25, P = 0.001 or less for all. Weaker predominantly non-significant correlations were found for cathepsin L, whereas cathepsin D was not related to any surrogate markers for health. No significant correlations were found between biomarkers and change in body fat over 2 years. Conclusion: Findings from this community-based cohort of young children show that surrogate markers for cardiovascular disease such as total fat mass, percent body fat, abdominal fat, body fat distribution, maximal oxygen uptake and pulse pressure were all associated with cystatin B. This was not found for cathepsin L or cathepsin D.
dc.language.isoeng
dc.subjectadipose tissue
dc.subjectfats
dc.subjectchildren
dc.subjectbiomarkers
dc.subjectblood pressure
dc.subjectanthropometry
dc.subjectcardiovascular diseases
dc.subjectregression analysis
dc.titleCystatin B, cathepsin L and D related to surrogate markers for cardiovascular disease in children
dc.typePeer reviewed
dc.typeJournal article
dc.description.versionpublishedVersion
dc.rights.holder© 2017 Dencker et al.
dc.source.pagenumber1-13
dc.source.volume12
dc.source.journalPLoS ONE
dc.source.issue11
dc.identifier.doi10.1371/journal.pone.0187494
dc.identifier.cristin1532223
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sports Medicine
cristin.unitcode150,34,0,0
cristin.unitnameSeksjon for idrettsmedisinske fag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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