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dc.contributor.authorGoharian, Tina S
dc.contributor.authorGoetze, Jens P
dc.contributor.authorFaber, Jens
dc.contributor.authorAndersen, Lars Bo
dc.contributor.authorGrøntved, Anders
dc.contributor.authorJeppesen, Jørgen L.
dc.date.accessioned2018-04-20T10:13:21Z
dc.date.available2018-04-20T10:13:21Z
dc.date.created2017-10-11T15:35:10Z
dc.date.issued2017
dc.identifier.citationAmerican Journal of Hypertension. 2017, 30, 561-568.nb_NO
dc.identifier.issn0895-7061
dc.identifier.urihttp://hdl.handle.net/11250/2495267
dc.descriptionI Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på academic.oup.com / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The definitive version is available at academic.oup.comnb_NO
dc.description.abstractBACKGROUND: In middle-aged and elderly populations, circulating natriuretic peptide concentrations are negatively associated with several components of the metabolic syndrome. Whether these negative associations are also present in healthy adolescents and young adults from the general population are unknown. METHODS: In a cross-sectional setting, we measured plasma concentrations of mid-regional proatrial natriuretic peptide (MR-proANP) in 343 adolescents (age 14–16 years) and 616 young adults (age 20–28 years) from the Danish site of the European Youth Heart Study, which is a population-based study of cardiovascular disease risk factors in children, adolescents and young adults. We used linear regression analysis to examine the associations, expressed as standardized regression coefficients, of various variables of interest with MR-proANP stratified according to age group, adjusting for age and gender. RESULTS: Among the young adults, MR-proANP was negatively associated with body mass index (BMI) (β = −0.10, P = 0.02), waist circumference (WC) (β = −0.14, P < 0.001), systolic blood pressure (BP) (β = −0.08, P = 0.03), diastolic BP (β = −0.23, P < 0.001), insulin (β = −0.15, P < 0.001), and triglycerides (β = −0.14, P < 0.001). Among the adolescents a somehow different pattern was observed since MR-proANP was not significantly associated with BMI (β = −0.00, P = 0.98), WC (β = −0.01, P = 0.90) and insulin (β = −0.02, P = 0.69). Nevertheless, among the adolescents, MR-proANP was negatively associated with triglycerides (β = −0.13, P = 0.01), diastolic BP (β = −0.12, P = 0.01) and systolic BP (β = −0.10, P = 0.10), although the latter association was of borderline significance. CONCLUSIONS: The young adults displayed significant negative associations between MR-proANP and several components of the metabolic syndrome, whereas such associations were not found among the adolescents besides triglycerides and diastolic BP.nb_NO
dc.language.isoengnb_NO
dc.subjectanthropometrynb_NO
dc.subjectatrial natriuretic peptidenb_NO
dc.subjectblood pressurenb_NO
dc.subjectbody mass indexnb_NO
dc.subjectmetabolismnb_NO
dc.subjectinsulinnb_NO
dc.subjectnatriuretic peptidesnb_NO
dc.subjectwaist circumferencenb_NO
dc.titleAssociations of proatrial natriuretic peptide with components of the metabolic syndrome in adolescents and young adults from the general populationnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.source.pagenumber561-568nb_NO
dc.source.volume30nb_NO
dc.source.journalAmerican Journal of Hypertensionnb_NO
dc.source.issue6nb_NO
dc.identifier.doi10.1093/ajh/hpx026
dc.identifier.cristin1503878
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sport Medicinenb_NO
cristin.unitcode150,34,0,0
cristin.unitnameSeksjon for idrettsmedisinske fag
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode1


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