Vis enkel innførsel

No Association Between Risk of Anterior Cruciate Ligament Rupture and Selected Candidate Collagen Gene Variants in Female Elite Athletes From High-Risk Team Sports

dc.contributor.authorSivertsen, Einar
dc.contributor.authorFoss, Kari Bente
dc.contributor.authorKristianslund, Eirik
dc.contributor.authorSiebke, Anne-Marie
dc.contributor.authorParkkari, Jari
dc.contributor.authorLehtimäki, Terho
dc.contributor.authorMononen, Nina
dc.contributor.authorPasanen, Kati
dc.contributor.authorBahr, Roald
dc.date.accessioned2019-05-15T14:36:35Z
dc.date.available2019-05-15T14:36:35Z
dc.date.created2018-11-30T13:56:49Z
dc.date.issued2019
dc.identifier.citationAmerican Journal of Sports Medicine. 2019, 47, 52-58.nb_NO
dc.identifier.issn0363-5465
dc.identifier.urihttp://hdl.handle.net/11250/2597733
dc.descriptionI Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på sagepub.com / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The definitive version is available at sagepub.comnb_NO
dc.description.abstractBackground: Several single-nucleotide variants (SNVs) in collagen genes have been reported as predisposing factors for anterior cruciate ligament (ACL) tears. However, the evidence is conflicting and does not support a clear association between genetic variants and risk of ACL ruptures. Purpose: To assess the association of previously identified candidate SNVs in genes encoding for collagen and the risk of ACL injury in a population of elite female athletes from high-risk team sports. Study Design: Cohort study; Level of evidence, 2. Methods: A total of 851 female Norwegian and Finnish elite athletes from team sports were included from 2007 to 2011. ACL injuries acquired before inclusion in the cohort were registered by interview. The participants were followed prospectively through 2015 to record new complete ACL injuries. Six selected SNVs were genotyped (COL1A1: rs1800012, rs1107946; COL3A1: rs1800255; COL5A1: rs12722, rs13946; COL12A1: rs970547). Results: No associations were found between ACL rupture and the SNVs tested. Conclusion: The study does not support a role of the 6 selected SNVs in genes encoding for collagen proteins as risk factors for ACL injury. Clinical Relevance: Genetic profiling to identify athletes at high risk for ACL rupture is not yet feasible.nb_NO
dc.language.isoengnb_NO
dc.subjectgenetic risknb_NO
dc.subjectfemale athletenb_NO
dc.subjectanterior cruciate ligamentnb_NO
dc.subjectteam sportsnb_NO
dc.subjectgene polymorphismsnb_NO
dc.titleNo Association Between Risk of Anterior Cruciate Ligament Rupture and Selected Candidate Collagen Gene Variants in Female Elite Athletes From High-Risk Team Sportsnb_NO
dc.typeJournal articlenb_NO
dc.typePeer reviewednb_NO
dc.description.versionacceptedVersionnb_NO
dc.rights.holder© 2018 The Author(s).nb_NO
dc.source.pagenumber52-58nb_NO
dc.source.volume47nb_NO
dc.source.journalAmerican Journal of Sports Medicinenb_NO
dc.source.issue1nb_NO
dc.identifier.doi10.1177/0363546518808467
dc.identifier.cristin1637621
dc.description.localcodeSeksjon for idrettsmedisinske fag / Department of Sports Medicinenb_NO
cristin.unitcode150,34,0,0
cristin.unitnameSeksjon for idrettsmedisinske fag
cristin.ispublishedtrue
cristin.fulltextpostprint
cristin.qualitycode2


Tilhørende fil(er)

Thumbnail
Filnavn:
Sivertsen+AmJSportMed+2018.pdf
Størrelse:
524.6Kb
Format:
PDF
Åpne

Denne innførselen finnes i følgende samling(er)

Vis enkel innførsel