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dc.contributor.authorKoivisto, Anu
dc.contributor.authorOlsen, Thomas
dc.contributor.authorPaur, Ingvild
dc.contributor.authorPaulsen, Gøran
dc.contributor.authorBastani, Nasser Ezzatkhah
dc.contributor.authorGarthe, Ina
dc.contributor.authorRaastad, Truls
dc.contributor.authorMatthews, Jason
dc.contributor.authorBlomhoff, Rune
dc.contributor.authorBøhn, Siv Kjølsrud
dc.date.accessioned2020-03-19T08:45:28Z
dc.date.available2020-03-19T08:45:28Z
dc.date.created2019-06-14T09:58:29Z
dc.date.issued2019
dc.identifier.citationPLoS ONE. 2019, 14(6), e0217895.en_US
dc.identifier.issn1932-6203
dc.identifier.urihttps://hdl.handle.net/11250/2647487
dc.descriptionThis is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
dc.description.abstractBackground: Various altitude training regimes, systematically used to improve oxygen carrying capacity and sports performance, have been associated with increased oxidative stress and inflammation. We investigated whether increased intake of common antioxidant-rich foods attenuates these processes. Methods: In a randomized controlled trial, 31 elite endurance athletes (23 ± 5 years), ingested antioxidant-rich foods (n = 16), (> doubling their usual intake), or eucaloric control foods (n = 15) during a 3-week altitude training camp (2320 m). Fasting blood and urine samples were collected 7 days pre-altitude, after 5 and 18 days at altitude, and 7 days post-altitude. Change over time was compared between the groups using mixed models for antioxidant capacity [uric acid-free (ferric reducing ability of plasma (FRAP)], oxidative stress (8-epi-PGF2α) and inflammatory biomarkers (IFNγ, IL1α, IL1RA, IL1β, IL2, IL5, IL6, IL7, IL10, IL12p70, IL13, IL17, TNFα, MCP-1 and micro-CRP). The cytokine response to a stress-test (VO2max ramp test or 100 m swimming) was assessed at pre- and post-altitude. Results: FRAP increased more in the antioxidant compared to the control group (p = 0.034). IL13 decreased in the antioxidant group, while increasing in the controls (p = 0.006). A similar trend was seen for IL6 (p = 0.062). A larger decrease in micro-CRP was detected in the antioxidant group compared to controls (β: -0.62, p = 0.02). We found no group differences for the remaining cytokines. 8-epi-PGF2α increased significantly in the whole population (p = 0.033), regardless group allocation. The stress response was significantly larger post-altitude compared with pre-altitude for IL1β, IL6, IL7, IL13, IL12p70 and TNFα, but we found no group differences. Conclusions: Increased intake of antioxidant-rich foods elevated the antioxidant capacity and attenuated some of the altitude-induced systemic inflammatory biomarkers in elite athletes. The antioxidant intervention had no impact on the altitude-induced oxidative stress or changes in acute cytokine responses to exercise stress-tests.en_US
dc.language.isoengen_US
dc.relation.urihttps://journals.plos.org/plosone/article?id=10.1371/journal.pone.0217895
dc.subjectantioxidantsen_US
dc.subjectcytokinesen_US
dc.subjectfluorescence recovery after photobleachingen_US
dc.subjectinflammationen_US
dc.subjectoxidative stressen_US
dc.subjectswimmingen_US
dc.subjectbiomarkersen_US
dc.subjectblood plasmaen_US
dc.titleEffects of antioxidant-rich foods on altitude-induced oxidative stress and inflammation in elite endurance athletes: A randomized controlled trialen_US
dc.typePeer revieweden_US
dc.typeJournal articleen_US
dc.description.versionpublishedVersionen_US
dc.rights.holder© 2019 Koivisto et al.en_US
dc.subject.nsiVDP::Idrettsmedisinske fag: 850en_US
dc.subject.nsiVDP::Sports medicine: 850en_US
dc.source.pagenumber19en_US
dc.source.volume14en_US
dc.source.journalPLoS ONEen_US
dc.source.issue6en_US
dc.identifier.doihttps://doi.org/10.1371/journal.pone.0217895
dc.identifier.cristin1704868
dc.description.localcodeSeksjon for fysisk prestasjonsevne / Department of Physical Performanceen_US
cristin.unitcode150,31,0,0
cristin.unitcode150,34,0,0
cristin.unitnameSeksjon for fysisk prestasjonsevne
cristin.unitnameSeksjon for idrettsmedisinske fag
cristin.ispublishedtrue
cristin.fulltextoriginal
cristin.qualitycode1


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