dc.contributor.author | Ellefsen, Stian | |
dc.contributor.author | Vikmoen, Olav | |
dc.contributor.author | Slettaløkken, Gunnar | |
dc.contributor.author | Whist, Jon Elling | |
dc.contributor.author | Nygård, Håvard | |
dc.contributor.author | Hollan, Ivana | |
dc.contributor.author | Rauk, Irene | |
dc.contributor.author | Vegge, Geir | |
dc.contributor.author | Strand, Tor A. | |
dc.contributor.author | Raastad, Truls | |
dc.contributor.author | Rønnestad, Bent | |
dc.date.accessioned | 2015-06-03T10:37:06Z | |
dc.date.available | 2015-06-03T10:37:06Z | |
dc.date.issued | 2014-06-07 | |
dc.identifier.citation | European Journal of Applied Physiology. 2014, 114, 1875-1888 | nb_NO |
dc.identifier.uri | http://hdl.handle.net/11250/284500 | |
dc.description | I Brage finner du siste tekst-versjon av artikkelen, og den kan inneholde ubetydelige forskjeller fra forlagets pdf-versjon. Forlagets pdf-versjon finner du på www.springer.com: http://dx.doi.org/10.1007/s00421-014-2922-x / In Brage you'll find the final text version of the article, and it may contain insignificant differences from the journal's pdf version. The original publication is available at www.springer.com: http://dx.doi.org/10.1007/s00421-014-2922-x | nb_NO |
dc.description.abstract | Purpose: To investigate the effects of strength training on abundances of irisin-related biomarkers in skeletal muscle and blood of untrained young women, and their associations with body mass composition, muscle phenotype and levels of thyroid hormones.
Methods: Eighteen untrained women performed 12 weeks of progressive whole-body heavy strength training, with measurement of strength, body composition, expression of irisin-related genes (FNDC5 and PGC1α) in two different skeletal muscles, and levels of serum-irisin and -thyroid hormones, before and after the training intervention.
Results: The strength training intervention did not result in changes in serum-irisin or muscle FNDC5 expression, despite considerable effects on strength, lean body mass (LBM) and skeletal muscle phenotype. Our data indicate that training affects irisin biology in a LBM-dependent manner. However, no association was found between steady-state serum-irisin or training-associated changes in serum-irisin and alterations in body composition. FNDC5 expression was higher in m.Biceps brachii than in m.Vastus lateralis, with individual expression levels being closely correlated, suggesting a systemic mode of transcriptional regulation. In pre-biopsies, FNDC5 expression was correlated with proportions of aerobic muscle fibers, a relationship that disappeared in post-biopsies. No association was found between serum-thyroid hormones and FNDC5 expression or serum-irisin.
Conclusion: No evidence was found for an effect of strength training on irisin biology in untrained women, though indications were found for a complex interrelationship between irisin, body mass composition and muscle phenotype. FNDC5 expression was closely associated with muscle fiber composition in untrained muscle. | nb_NO |
dc.language.iso | eng | nb_NO |
dc.publisher | Springer Verlag | nb_NO |
dc.subject | irisin | nb_NO |
dc.subject | FnDc5 | nb_NO |
dc.subject | lean body mass | nb_NO |
dc.subject | fat mass | nb_NO |
dc.subject | muscle fiber | nb_NO |
dc.subject | skeletal muscle | nb_NO |
dc.subject | strength training | nb_NO |
dc.subject | thyroid hormones | nb_NO |
dc.subject | exercise | nb_NO |
dc.subject | myosin heavy chain | nb_NO |
dc.subject | MHC | nb_NO |
dc.subject | MyHC | nb_NO |
dc.subject | mRNA | nb_NO |
dc.subject | real-time rt-Pcr | nb_NO |
dc.subject | qrt-Pcr | nb_NO |
dc.subject | metabolism | nb_NO |
dc.title | Irisin and FNDC5: effects of 12-week strength training, and relations to muscle phenotype and body mass composition in untrained women | nb_NO |
dc.type | Journal article | nb_NO |
dc.type | Peer reviewed | nb_NO |
dc.subject.nsi | VDP::Mathematics and natural science: 400::Basic biosciences: 470 | nb_NO |
dc.source.journal | European Journal of Applied Physiology | nb_NO |
dc.description.localcode | Seksjon for fysisk prestasjonsevne / Department of Physical Performance | nb_NO |