• Bivariate genome-wide association meta-analysis of pediatric musculoskeletal traits reveals pleiotropic effects at the SREBF1/TOM1L2 locus 

      Medina-Gomez, Carolina; Kemp, John P.; Dimou, Niki L.; Kreiner, Eskil; Chesi, Alessandra; Zemel, Babette S.; Bønnelykke, Klaus; Boer, Cindy G.; Ahluwalia, Tarunveer S.; Bisgaard, Hans; Evangelou, Evangelos; Heppe, Denise H. M.; Bonewald, Lynda F.; Gorski, Jeffrey P.; Ghanbari, Mohsen; Demissie, Serkalem; Duque, Gustavo; Maurano, Matthew T.; Kiel, Douglas P.; Hsu, Yi-Hsiang; van der Erden, Bram C. J.; Ackert-Bicknell, Cheryl; Reppe, Sjur; Gautvik, Kaare M.; Raastad, Truls; Karasik, David; van de Peppel, Jeroen; Jaddoe, Vincent W. V.; Uitterlinden, Andre G.; Tobias, Jonathan H.; Grant, Struan F. A.; Bagos, Pantelis G.; Evans, David M.; Rivadeneira, Fernando (Journal article; Peer reviewed, 2017)
      Bone mineral density is known to be a heritable, polygenic trait whereas genetic variants contributing to lean mass variation remain largely unknown. We estimated the shared SNP heritability and performed a bivariate GWAS ...
    • Different resistance exercise loading paradigms similarly affect skeletal muscle gene expression patterns of myostatin-related targets and mTORC1 signaling markers 

      McIntosh, Mason C; Godwin, Joshua S.; Michel, J. Max; Plotkin, Daniel L.; Ziegenfuss, Tim N.; Lopez, Hector L.; Smith, Ryan; Dalbo, Vincent J.; Sexton, Casey L.; Ruple, Bradley A.; Dwaraka, Varun B.; Sharples, Adam P.; Mobley, Christopher Brooks; Vann, Christopher G.; Roberts, Michael D. (Peer reviewed; Journal article, 2023)
      Although transcriptome profiling has been used in several resistance training studies, the associated analytical approaches seldom provide in-depth information on individual genes linked to skeletal muscle hypertrophy. ...
    • Evidence against a beneficial effect of irisin in humans 

      Raschke, Silja; Elsen, Manuela; Gassenhuber, Hans; Sommerfeld, Mark; Schwahn, Uwe; Brockmann, Barbara; Jung, Raphael; Wisløff, Ulf; Tjønna, Arnt E.; Raastad, Truls; Hallén, Jostein; Norheim, Frode; Drevon, Christian A.; Romacho, Tania; Eckardt, Kristin; Eckel, Juergen (Journal article; Peer reviewed, 2013-09-11)
      Brown adipose tissue has gained interest as a potential target to treat obesity and metabolic diseases. Irisin is a newly identified hormone secreted from skeletal muscle enhancing browning of white fat cells, which improves ...
    • Low-input RNA-sequencing in patients with cartilage lesions, osteoarthritis, and healthy cartilage 

      Wang, Katherine; Esbensen, Qin Ying; Karlsen, Tommy Aleksander; Eftang, Cathrine Nørstad; Owesen, Christian; Årøen, Asbjørn; Jakobsen, Rune Bruhn (Peer reviewed; Journal article, 2021)
      Objective To analyze and compare cartilage samples from 3 groups of patients utilizing low-input RNA-sequencing. Design Cartilage biopsies were collected from patients in 3 groups (n = 48): Cartilage lesion (CL) ...
    • Mechanical loading of bioengineered skeletal muscle in vitro recapitulates gene expression signatures of resistance exercise in vivo 

      Turner, Daniel C.; Gorski, Piotr Patryk; Seaborne, Robert A.; Viggars, Mark; Murphy, Mark; Jarvis, Jonathan C.; Martin, Neil R. W.; Stewart, Claire E.; Sharples, Adam P. (Peer reviewed; Journal article, 2021)
      Understanding the role of mechanical loading and exercise in skeletal muscle (SkM) is paramount for delineating the molecular mechanisms that govern changes in muscle mass. However, it is unknown whether loading of ...
    • MicroRNAs in muscle: characterizing the powerlifter phenotype 

      D'Souza, Randall F.; Bjørnsen, Thomas; Zeng, Nina; Aasen, Kirsten M. M.; Raastad, Truls; Cameron-Smith, David; Mitchell, Cameron J. (Journal article; Peer reviewed, 2017-06-07)
      Powerlifters are the epitome of muscular adaptation and are able to generate extreme forces. The molecular mechanisms underpinning the significant capacity for force generation and hypertrophy are not fully elucidated. ...
    • Molecular responses to acute exercise and their relevance for adaptations in skeletal muscle to exercise training 

      Egan, Brendan; Sharples, Adam (Peer reviewed; Journal article, 2022)
      Repeated, episodic bouts of skeletal muscle contraction undertaken frequently as structured exercise training is a potent stimulus for physiological adaptation in many organs. Specifically in skeletal muscle, remarkable ...
    • Vitamin C and E supplementation does not affect heat shock proteins or endogenous antioxidants in trained skeletal muscles during 12 weeks of strength training 

      Cumming, Kristoffer Toldnes; Raastad, Truls; Sørstrøm, Andreas Natvig; Paronetto, Maria Paola; Mercatelli, Neri; Ugelstad, Ingrid; Caporossi, Daniela; Paulsen, Gøran (Journal article; Peer reviewed, 2017)
      Background: Supplementation with large doses of antioxidants, such as vitamin C and E, has been shown to blunt some adaptations to endurance training. The effects of antioxidant supplementation on adaptations to strength ...