dc.contributor.author | Berglund, Ida Johnsen | |
dc.contributor.author | Vesterbekkmo, Elisabeth Kleivhaug | |
dc.contributor.author | Retterstøl, Kjetil | |
dc.contributor.author | Anderssen, Sigmund Alfred | |
dc.contributor.author | Singh, Maria A. Fiatarone | |
dc.contributor.author | Helge, Jørn Wulff | |
dc.contributor.author | Lydersen, Stian | |
dc.contributor.author | Wisløff, Ulrik | |
dc.contributor.author | Stensvold, Dorthe | |
dc.date.accessioned | 2022-03-22T01:06:04Z | |
dc.date.available | 2022-03-22T01:06:04Z | |
dc.date.created | 2021-11-18T10:36:44Z | |
dc.date.issued | 2021 | |
dc.identifier.citation | Mayo Clinic Proceedings: Innovations, Quality & Outcomes. 2021, 5(5), Side 859-871. | en_US |
dc.identifier.issn | 2542-4548 | |
dc.identifier.uri | https://hdl.handle.net/11250/2986662 | |
dc.description | This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). | en_US |
dc.description.abstract | Objective: To examine whether 5 years of high-intensity interval training (HIIT) increases high-density lipoprotein cholesterol (HDL-C) concentration more than moderate-intensity continuous training (MICT) and control (CON) in older men and women.
Methods: A total of 1567 older adults (790 [50.4%] women) were randomized (2:1:1) to either CON (n=780; asked to follow the national recommendations for physical activity) or 2 weekly sessions of HIIT (10-minute warm-up followed by 4×4-minute intervals at ∼90% of peak heart rate) or MICT (50 minutes of continuous work at ∼70% of peak heart rate). Serum HDL-C concentration was measured by standard procedures at baseline and at 1 year, 3 years, and 5 years. The study took place between August 21, 2012, and June 31, 2018. Linear mixed models were used to determine between-group differences during 5 years using the per protocol approach.
Results: Men in HIIT had a smaller reduction in HDL-C (−1.2%) than men in CON (−6.9%) and MICT (−7.8%) after 5 years (P=.01 and P=.03 for CON vs HIIT and MICT vs HIIT, respectively). No effect of exercise intensity on HDL-C was seen in women. Changes in peak oxygen uptake were associated with changes in HDL-C in both men and women, whereas changes in body weight and fat mass were not.
Conclusion: In men, HIIT seems to be the best strategy to prevent a decline in HDL-C during a 5-year period. No effect of exercise intensity was seen for older women.
Trial registration: ClinicalTrials.gov identifier: NCT01666340. | en_US |
dc.language.iso | eng | en_US |
dc.subject | cardiovascular disease | en_US |
dc.subject | CON | en_US |
dc.subject | control | en_US |
dc.subject | CVD | en_US |
dc.subject | HDL-C | en_US |
dc.subject | high-density lipoprotein cholesterol | en_US |
dc.subject | high-intensity interval training | en_US |
dc.subject | HIIT | en_US |
dc.subject | HRpeak | en_US |
dc.subject | LDL-C | en_US |
dc.subject | lipid-modifying agent | en_US |
dc.subject | LMA | en_US |
dc.subject | low-density lipoprotein cholesterol | en_US |
dc.subject | MICT | en_US |
dc.subject | moderate-intensity continuous training | en_US |
dc.subject | peak heart rate | en_US |
dc.subject | peak oxygen uptake | en_US |
dc.subject | Vo2peak | en_US |
dc.title | The long-term effect of different exercise intensities on high-density lipoprotein cholesterol in older men and women using the per protocol approach: The Generation 100 study | en_US |
dc.type | Peer reviewed | en_US |
dc.type | Journal article | en_US |
dc.description.version | publishedVersion | en_US |
dc.rights.holder | © 2021 The Authors | en_US |
dc.source.pagenumber | 859-871 | en_US |
dc.source.volume | 5 | en_US |
dc.source.journal | Mayo Clinic Proceedings: Innovations, Quality & Outcomes | en_US |
dc.source.issue | 5 | en_US |
dc.identifier.doi | 10.1016/j.mayocpiqo.2021.07.002 | |
dc.identifier.cristin | 1955855 | |
dc.description.localcode | Institutt for idrettsmedisinske fag / Department of Sports Medicine | en_US |
cristin.ispublished | true | |
cristin.fulltext | original | |
cristin.qualitycode | 1 | |