Browsing Brage NIH by Author "Jensen, Jørgen"
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Eight sessions of endurance training decrease fasting glucose and improve glucose tolerance in middle-aged overweight males
Jelstad, Stian S.; Valsdottir, Thorhildur; Johansen, Egil Ivar; Jensen, Jørgen (Peer reviewed; Journal article, 2019)Exercise improves metabolic regulation and reduces the risk of developing type 2 diabetes and other metabolic diseases. The recommendations for exercise are rather general and the health benefits of controlled training ... -
Energy expenditure and intensity of ritual jumping–dancing in male Maasai
Christensen, Dirk L.; Westgate, Kate; Griffiths, Lewis; Sironga, Joseph; Maro, Venance P.; Helge, Jørn W.; Larsen, Steen; Bygbjerg, Ib C.; Ramaiya, Kaushik L.; Jensen, Jørgen; Brage, Søren Karl (Peer reviewed; Journal article, 2023)Objectives: Traditional jumping–dance rituals performed by Maasai men involve prolonged physical exertion that may contribute significantly to overall physical activity level. We aimed to objectively quantify the metabolic ... -
Exercise in vivo marks human myotubes in vitro: Training-induced increase in lipid metabolism
Lund, Jenny; Rustan, Arild; Løvsletten, Nils Gunnar; Mudry, Jonathan M.; Langleite, Torgrim Mikal; Feng, Yuan Zeng; Stensrud, Camilla; Brubak, Mari G; Drevon, Christian A; Birkeland, Kåre I.; Kolnes, Kristoffer Jensen; Johansen, Egil Ivar; Tangen, Daniel S.; Stadheim, Hans Kristian; Gulseth, Hanne Løvdal; Krook, Anna; Kase, Eili Tranheim; Jensen, Jørgen; Thoresen, G. Hege (Peer reviewed; Journal article, 2017)Background and aims: Physical activity has preventive as well as therapeutic benefits for overweight subjects. In this study we aimed to examine effects of in vivo exercise on in vitro metabolic adaptations by studying ... -
Exhaustive exercise and post-exercise protein plus carbohydrate supplementation affect plasma and urine concentrations of sulfur amino acids, the ratio of methionine to homocysteine and glutathione in elite male cyclists
Olsen, Thomas; Sollie, Ove; Nurk, Eha; Turner, Cheryl; Jernerén, Fredrik; Ivy, John L.; Vinknes, Kathrine; Clauss, Matthieu; Refsum, Helga Margaretha; Jensen, Jørgen (Peer reviewed; Journal article, 2020)Plasma and tissue sulfur amino acid (SAA) availability are crucial for intracellular methylation reactions and cellular antioxidant defense, which are important processes during exercise and in recovery. In this randomized, ... -
GDF15 provides an endocrine signal of nutritional stress in mice and humans
Patel, Satish; Álvarez-Guaita, Anna; Melvin, Audrey; Rimmington, Debra; Dattilo, Alessia; Miedzybrodzka, Emily L.; Cimino, Irene; Maurin, Anne-Catherine; Roberts, Geoffrey P.; Meek, Claire L.; Virtue, Samuel; Sparks, Lauren M.; Parsons, Stephanie A.; Redman, Leanne M.; Bray, George A.; Liou, Alice P.; Woods, Rachel M.; Parry, Sion A.; Jeppesen, Per Bendix; Kolnes, Anders Jensen; Harding, Heather P.; Ron, David; Vidal-Puig, Antonio; Reimann, Frank; Gribble, Fiona M.; Hulston, Carl J.; Farooqi, I. Sadaf; Fafournoux, Pierre; Smith, Steven R.; Jensen, Jørgen; Breen, Danna; Wu, Zhidan; Zhang, Bei B.; Coll, Anthony P.; Savage, David B.; O'Rahilly, Stephen (Peer reviewed; Journal article, 2019)GDF15 is an established biomarker of cellular stress. The fact that it signals via a specific hindbrain receptor, GFRAL, and that mice lacking GDF15 manifest diet-induced obesity suggest that GDF15 may play a physiological ... -
Global mRNA sequencing of human skeletal muscle: Search for novel exercise-regulated myokines
Pourteymour, Shirin; Eckardt, Kristin; Holen, Torgeir; Langleite, Torgrim Mikal; Lee, Sindre; Jensen, Jørgen; Birkeland, Kåre I.; Drevon, Christian A.; Hjorth, Marit (Journal article; Peer reviewed, 2017-01)Objective: Skeletal muscle is an important secretory organ, producing and releasing numerous myokines, which may be involved in mediating beneficial health effects of physical activity. More than 100 myokines have been ... -
Glucose metabolism and metabolic flexibility in cultured skeletal muscle cells is related to exercise status in young male subjects
Lund, Jenny; Tangen, Daniel S.; Wiig, Håvard; Stadheim, Hans Kristian; Siw, Anette Helle; Birk, Jesper B.; Ingemann-Hansen, Thorsten; Rustan, Arild; Thoresen, G. Hege; Wojtaszewski, Jørgen F.P.; Kase, Eili Tranheim; Jensen, Jørgen (Journal article; Peer reviewed, 2017)We hypothesised that skeletal muscles of healthy young people have a large variation in oxidative capacity and fibre-type composition, and aimed therefore to investigate glucose metabolism in biopsies and myotubes isolated ... -
Higher lipid turnover and oxidation in cultured human myotubes from athletic versus sedentary young male subjects
Lund, Jenny; Helle, Siw A.; Li, Yuchuan; Løvsletten, Nils Gunnar; Stadheim, Hans Kristian; Jensen, Jørgen; Kase, Eili Tranheim; Thoresen, G. Hege; Rustan, Arild (Journal article; Peer reviewed, 2018)In this study we compared fatty acid (FA) metabolism in myotubes established from athletic and sedentary young subjects. Six healthy sedentary (maximal oxygen uptake (VO2max)≤ 46 ml/kg/min) and six healthy athletic ... -
Identification and validation of novel contraction-regulated myokines released from primary human skeletal muscle cells
Raschke, Silja; Eckardt, Kristin; Holven, Kirsten Bjørklund; Jensen, Jørgen; Eckel, Jürgen (Journal article; Peer reviewed, 2013-04-24)Proteins secreted by skeletal muscle, so called myokines, have been shown to affect muscle physiology and additionally exert systemic effects on other tissues and organs. Although recent profiling studies have identified ... -
Increased Mass-Specific Maximal Fat Oxidation Rate with Small versus Large Muscle Mass Exercise
Skattebo, Øyvind; Peci, Dafina; Clauss, Matthieu; Johansen, Egil Ivar; Jensen, Jørgen (Peer reviewed; Journal article, 2022)Introduction: Skeletal muscle perfusion and oxygen (O2) delivery are restricted during whole-body exercise due to a limited cardiac output (Q[Combining Dot Above]). This study investigated the role of reducing central ... -
Insulin induces an increase in cytosolic glucose levels in 3T3-L1 cells with inhibited glycogen synthase activation
Chowdhury, Helena H.; Kreft, Marko; Jensen, Jørgen; Zorec, Robert (Journal article; Peer reviewed, 2014-10-02)Glucose is an important source of energy for mammalian cells and enters the cytosol via glucose transporters. It has been thought for a long time that glucose entering the cytosol is swiftly phosphorylated in most cell ... -
Intake of protein plus carbohydrate during the first two hours after exhaustive cycling improves performance the following day
Rustad, Per Inge; Sailer, Manuela; Cumming, Kristoffer Toldnes; Jeppesen, Per Bendix; Kolnes, Kristoffer Jensen; Sollie, Ove; Franch, Jesper; Ivy, John L.; Daniel, Hannelore; Jensen, Jørgen (Journal article; Peer reviewed, 2016-04-14)Intake of protein immediately after exercise stimulates protein synthesis but improved recovery of performance is not consistently observed. The primary aim of the present study was to compare performance 18 h after ... -
Interaction between plasma fetuin‐A and free fatty acids predicts changes in insulin sensitivity in response to long‐term exercise
Lee, Sindre; Norheim, Frode; Gulseth, Hanne L.; Langleite, Torgrim M.; Kolnes, Kristoffer J.; Tangen, Daniel S.; Stadheim, Hans Kristian; Gilfillan, Gregor D.; Holen, Torgeir; Birkeland, Kåre I,; Jensen, Jørgen; Drevon, Christian A. (Journal article; Peer reviewed, 2017-03)The hepatokine fetuin‐A can together with free fatty acids (FFAs) enhance adipose tissue (AT) inflammation and insulin resistance via toll‐like receptor 4 (TLR4). Although some of the health benefits of exercise can be ... -
Low-carbohydrate high-fat diet and exercise: Effect of a 10-week intervention on body composition and CVD risk factors in overweight and obese women—a randomized controlled trial
Valsdottir, Thorhildur Ditta; Øvrebø, Bente; Falck, Thea Martine; Litleskare, Sigbjørn; Johansen, Egil Ivar; Henriksen, Christine; Jensen, Jørgen (Peer reviewed; Journal article, 2020)We assessed the effect of weight-loss induced with a low-carbohydrate-high-fat diet with and without exercise, on body-composition, cardiorespiratory fitness and cardiovascular risk factors. A total of 57 overweight and ... -
Molecular nutrition research: the modern way of performing nutritional science
Norheim, Frode; Gjelstad, Ingrid Merethe Fange; Hjorth, Marit; Vinknes, Kathrine; Langleite, Torgrim Mikal; Jensen, Jørgen; Dalen, Knut Tomas; Karlsen, Anette; Kielland, Anders; Rustan, Arild; Drevon, Christian A. (Journal article; Peer reviewed, 2012-12-03)In spite of amazing progress in food supply and nutritional science, and a striking increase in life expectancy of approximately 2.5 months per year in many countries during the previous 150 years, modern nutritional ... -
Plasma norepinephrine in hypertensive rats reflects α2-adrenoceptor release control only when re-uptake is inhibited
Berg, Torill; Walaas, S. Ivar; Roberg, Bjørg Åse; Huynh, Trang Thi Ngoc; Jensen, Jørgen (Journal article; Peer reviewed, 2012-11)α2-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Norepinephrine re-uptake–transporter effectively (NET) ... -
Plasma norepinephrine in hypertensive rats reflects α2-adrenoceptor release control only when re-uptake is inhibited
Berg, Torill; Walaas, Sven Ivar; Roberg, Bjørg Åse; Huynh, Trang Thi Ngoc; Jensen, Jørgen (Journal article; Peer reviewed, 2012-11-08)α2-adrenoceptors (AR) lower central sympathetic output and peripheral catecholamine release, thereby protecting against sympathetic hyperactivity and hypertension. Norepinephrine re-uptake–transporter effectively (NET) ... -
Potentiation increases peak twitch torque by enhancing rates of torque development and relaxation
Froyd, Christian; Beltrami, Fernando Gabe; Jensen, Jørgen; Noakes, Timothy David (Journal article; Peer reviewed, 2013)The aim of this study was to measure the extent to which potentiation changes in response to an isometric maximal voluntary contraction. Eleven physically active subjects participated in two separate studies. Single stimulus ... -
Protein intake during training sessions has no effect on performance and recovery during a strenuous training camp for elite cyclists
Hansen, Mette; Bangsbo, Jens; Jensen, Jørgen; Krause-Jensen, Matilde; Bibby, Bo Martin; Sollie, Ove; Hall, Ulrika Andersson; Madsen, Klavs (Academic article, 2016-03-05)Background: Training camps for top-class endurance athletes place high physiological demands on the body. Focus on optimizing recovery between training sessions is necessary to minimize the risk of injuries and improve ... -
Protein intake in the early recovery period after exhaustive exercise improves performance the following day
Sollie, Ove; Jeppesen, Per Bendix; Tangen, Daniel S.; Jernerén, Fredrik; Nellemann, Birgitte; Valsdottir, Thorhildur; Madsen, Klavs; Turner, Cheryl; Refsum, Helga; Skålhegg, Bjørn Steen; Ivy, John L.; Jensen, Jørgen (Journal article; Peer reviewed, 2018)The aim of the present study was to investigate the effect of protein and carbohydrate ingestion during early recovery from exhaustive exercise on performance after 18-h recovery. Eight elite cyclists (V̇o2max: 74.0 ± 1.6 ...